Multi-layer ceramide lamellar structure comprising fatty acid and neutralizing agent

Abstract

The present invention relates to a multilayer ceramide sheet structure comprising, in particular, a multilayer ceramide sheet structure comprising at least one of a fatty acid and a fatty alcohol, the molar ratio of any one of the above-mentioned fatty acids and fatty alcohols to the neutralizing agent is from 9: 1 to 1.2: 1, and the skin external application composition comprising the above-mentioned sheet-like structure is produced by using a multilayer sheet. The stabilization of the ceramide of the liquid crystal is excellent in phase stability.

Description

technical field [0001] This specification relates to a multi-layer ceramide lamellar structure (Multi ceramide lamellar structure) comprising a fatty acid and a neutralizing agent. Background technique [0002] The surface of human skin is formed by keratinocytes that degenerate from mature keratinocytes differentiated from the basal layer. These keratinocytes are bound by the double-chain sheet structure of ceramide present in large quantities in the stratum corneum, thus maintaining smooth and elastic skin. In the case of ceramides, two side-by-side alkyl chains form a rod morphology with hydroxyl (-OH) and carbonyl (C=O) functional groups, thus enabling the formation of structurally achievable sheet-like α-crystals (α -crystal), but the α crystal phase is metastable (metastable) state, thus easy to transform into γ crystal (γ-crystal). In addition, since it is poorly soluble in most oils, it is difficult to store it stably in the inner phase of an O / W emulsion, and ther...

AI Technical Summary

Problems solved by technology

In the case of ceramides, two side-by-side alkyl chains form a rod morphology with hydroxyl (-OH) and carbonyl (C=O) functional groups, thus enabling the formation of structurally achievable sheet-like α-crystals (α -crystal), but the α crystal phase is metastable (metastable) state, thus easy to transform into γ crystal (γ-crystal)

In addition, it is poorly soluble in most oils, so it is difficult to store stably in the inner phase of an O / W emulsion, and there is a limit to its use in large quantities in cosmetic formulations

Images