Multilayered ceramide sheet structures containing fatty acids and neutralizers

Abstract

The present invention relates to a multilayer ceramide sheet structure, specifically, including a multilayer ceramide sheet structure, the multilayer ceramide sheet structure comprising any one or more of fatty acids and fatty alcohols, and wherein and agent, the molar ratio of any one or more of the above-mentioned fatty acids and fatty alcohols to the neutralizing agent is 9:1 to 1.2:1, and the skin external preparation composition comprising the above-mentioned lamellar structure follows the use of multilayer lamellar liquid crystals. The stabilization of the ceramide and the phase stability are very excellent.

Description

technical field [0001] This specification relates to a multi-layer ceramide lamellar structure (Multi ceramide lamellar structure) comprising a fatty acid and a neutralizing agent. Background technique [0002] The surface of human skin is formed by keratinocytes that degenerate from mature keratinocytes differentiated from the basal layer. These keratinocytes are bound by the double-chain sheet structure of ceramide present in large quantities in the stratum corneum, thus maintaining smooth and elastic skin. In the case of ceramides, two side-by-side alkyl chains form a rod morphology with hydroxyl (-OH) and carbonyl (C=O) functional groups, thus enabling the formation of structurally achievable sheet-like α-crystals (α -crystal), but the α crystal phase is metastable (metastable) state, thus easy to transform into γ crystal (γ-crystal). In addition, since it is poorly soluble in most oils, it is difficult to store it stably in the inner phase of an O / W emulsion, and ther...

AI Technical Summary

Problems solved by technology

In the case of ceramides, two side-by-side alkyl chains form a rod morphology with hydroxyl (-OH) and carbonyl (C=O) functional groups, thus enabling the formation of structurally achievable sheet-like α-crystals (α -crystal), but the α crystal phase is metastable (metastable) state, thus easy to transform into γ crystal (γ-crystal)

In addition, it is poorly soluble in most oils, so it is difficult to store stably in the inner phase of an O / W emulsion, and there is a limit to its use in large quantities in cosmetic formulations

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