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Assembling system for PEGMa modified MoOx and thermosensitive PNIPAM microgel and preparation method thereof

A microgel and temperature-sensitive technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, liquid delivery, etc., can solve problems such as toxic side effects and difficult target release of drugs, and achieve low cost , easy operation, and mild reaction conditions

Active Publication Date: 2017-01-11
黑龙江省工研院资产经营管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the existing photothermal conversion materials are difficult to achieve precise and controllable targeted release of the loaded drug, and there are toxic and side effects, and to provide a PEGMa (methacrylate) modified MoOx (oxidized Molybdenum) and temperature-sensitive PNIPAM (polyisopropylacrylamide) microgel assembly system and preparation method thereof

Method used

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  • Assembling system for PEGMa modified MoOx and thermosensitive PNIPAM microgel and preparation method thereof
  • Assembling system for PEGMa modified MoOx and thermosensitive PNIPAM microgel and preparation method thereof
  • Assembling system for PEGMa modified MoOx and thermosensitive PNIPAM microgel and preparation method thereof

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specific Embodiment approach 1

[0027] Specific Embodiment 1: This embodiment is an assembly system of PEGMa-modified MoOx and temperature-sensitive PNIPAM microgel, the chemical formula of which is PEGMa-MoOx / P(NIPAM-co-MAA).

specific Embodiment approach 2

[0028] Specific embodiment two: In this embodiment, a method for preparing an assembly system of PEGMa modified MoOx and thermosensitive PNIPAM microgel is carried out according to the following steps:

[0029] 1. Dissolve 0.08-0.09g of ammonium molybdate in 15-25ml of deionized water under stirring;

[0030] 2. Dissolve 0.4-0.6g methacrylate in 10-15ml absolute ethanol solution;

[0031] 3. Mix the solutions obtained in step 1 and step 2, and then react at a constant temperature of 160°C for 10 to 14 hours by hydrothermal method, centrifuge the precipitate, wash and dry to obtain modified molybdenum oxide PEGMa-MoOx;

[0032] 4. Dissolve the above-mentioned PEGMa-MoOx in a beaker filled with 100ml of deionized water, stir for 30min, transfer to a 250ml round bottom flask, then add 1.5-2.0g of N-isopropylacrylamide, 82-328μL of methyl Acrylic acid, 0.05~0.07g N,N-methylene bisacrylamide and 0.05~0.06g sodium lauryl sulfate and mix well, heat up to 70°C at a heating rate of 1~...

specific Embodiment approach 3

[0036] Specific embodiment three: this embodiment is different from specific embodiment two in that: in step one, 0.0865 g of ammonium molybdate is dissolved in 20 ml of deionized water under stirring conditions. Other steps and parameters are the same as in the second embodiment.

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Abstract

The invention provides an assembling system for PEGMa modified MoOx and thermosensitive PNIPAM microgel and a preparation method thereof and relates to the assembling system for microgel and the preparation method thereof. The invention aims to solve the problems that the present photothermal conversion material is difficult to realize accurately controllable targeting release of the loaded drug and has toxic and side effects. The chemical formula of the system is PEGMa-MoOx / P(NIPAM-co-MAA). The method comprises the following steps: preparing PEGMa-MoOx and dissolving in deionized water; adding NIPAM, MAA, MBA and SDS and uniformly mixing; heating and introducing nitrogen; adding APS; and reacting and then centrifuging, washing, dialyzing and drying, thereby completing the preparation. The preparation method provided by the invention is simple and feasible, the cost is low, reaction conditions are mild, the operation is easy, the toxic and side effects are few, and the practicability is ultrahigh; the compound microgel can realize a targeting positioning function; and after a photo-thermal chemical treatment effect is achieved, the microgel can automatically degrade within 24h and can be discharged from the body.

Description

technical field [0001] The invention relates to a microgel assembly system and a preparation method thereof. Background technique [0002] According to the World Cancer Report, cancer has always been one of the leading causes of death, with an average of about 10 million new cases per year, and after conventional surgical resection, radiotherapy and chemotherapy, the average survival period is only 6-24 months . And conventional treatment has many disadvantages, such as killing normal tissue cells, increasing the metabolic rate of tumor cells and destroying the immune function of the body. In recent years, more and more people have begun to pay attention to the use of minimally invasive photothermal therapy to treat tumors, that is, to irradiate photothermal agents with near-infrared light of a certain wavelength to convert light energy into thermal energy and locally heat and kill tumor cells. Photothermal therapy can avoid the deficiency of conventional therapy, and also...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/06A61K47/54A61K47/32A61K31/704A61P35/00
CPCA61K9/06A61K31/704A61K41/0052A61K47/32
Inventor 唐冬雁齐小芳彭靖于在乾吕海涛杨旭包辛未
Owner 黑龙江省工研院资产经营管理有限公司
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