A kind of preparation method of promoting wound repair hydrocolloid dressing

Abstract

The invention discloses a preparation method for hydrocolloid dressing for promoting wound repairing, belonging to the technical field of medical dressing preparation. The method comprises the following steps: adding AFGF freeze-dried powder into a mixed solution of gelatin and carboxymethyl chitosan, thereby acquiring an AFGF-loaded transparent fluid; mixing with dissolving fluid of the matters including sodium carboxymethylcellulose, apple pectin, and the like; ultrasonically oscillating and then adding a cross-linking agent; performing cross-linking reaction under a certain temperature, acquiring reaction fluid and then mixing with resin viscous fluid, thereby acquiring a spinning solution; spinning by adopting a wet method, thereby acquiring an AFGF-loaded fiber; mixing with a pure cotton fiber and spinning to form cloth. According to the preparation method, the apple pectin is added, so that the water absorption lasting time of the dressing is increased and the gelling is quickened; styrene-isoprene segmented copolymer is added, so that the dressing viscidity and the peeling strength are effectively improved; hydrocolloid is prepared into weaved cloth and no film substrate is required, so that the problem of weak binding force between hydrocolloid and polymer film is solved and the wound repairing can be effectively promoted; the preparation method has wide application prospect.

Description

technical field [0001] The invention discloses a preparation method of a hydrocolloid dressing for promoting wound repair, and belongs to the technical field of preparation of medical dressings. Background technique [0002] Human skin can not only stabilize the internal environment of the human body, but also prevent the invasion of bacteria and microorganisms. When the skin is injured and the homeostasis of the internal environment is broken, medical dressings, as a medical wound healing material, can provide the necessary protection to the human body and reduce the degree of harm. Before the skin recovers, a good medical dressing can temporarily play a part of the skin covering function and provide favorable conditions for wound healing. [0003] Medical hydrocolloid dressing is a medical material made by mixing hydrocolloid particles with rubber substrate. This material combines the water-absorbing properties of hydrocolloid particles with the adhesive properties of ru...

AI Technical Summary

Problems solved by technology

[0005] The main technical problem to be solved by the present invention is that the binding force between the hydrocolloid particles and the polymer film in the existing hydrocolloid dressing is not strong, the water absorption of the dressing is small, and the swelling property is poor, which leads to fluid leakage and peeling off of the dressing easily The present invention provides a kind of hydrocolloid dressing that can promote wound repair by mixing hydrophilic material with rubber elastic body to obtain fiber and cotton fiber to obtain wound repair. Add the aFGF freeze-dried powder to the mixture of gelatin and carboxymethyl chitosan to obtain a transparent liquid loaded with aFGF, mix it with the solution of sodium carboxymethyl cellulose, apple pectin, etc. Linking agent, carry out cross-linking reaction at a certain temperature, get the reaction solution and mix it with the resin viscous solution to get the spinning solution, use the wet spinning method to get the loaded aFGF fiber, and mix it with pure cotton fiber to weave into cloth. The present invention improves the water absorption duration of the dressing and accelerates the gelation by adding apple pectin, and then effectively improves the viscosity and peel strength of the dressing by adding a styrene-isoprene block copolymer, and the present invention will The preparation of hydrocolloids into textile fabrics does not require a film substrate, which solves the problem of weak bonding between hydrocolloids and polymer films, can effectively promote wound recovery, and has broad application prospects