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Material for tumor photothermic treatment and preparation method and application thereof

A heat treatment and light-induced technology, applied in the field of biomedicine, can solve the problems of cell damage, low treatment efficiency, and low selectivity of chemotherapy drugs, etc., and achieve the effect of low cytotoxicity and strong tissue penetration

Inactive Publication Date: 2017-02-01
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the selectivity of chemotherapy drugs is not strong, it will inevitably damage the normal cells of the human body while destroying cancer cells, resulting in adverse drug reactions.
In other words, the high toxicity and side effects of chemotherapy and the low treatment efficiency have become the two bottlenecks restricting its therapeutic effect

Method used

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  • Material for tumor photothermic treatment and preparation method and application thereof
  • Material for tumor photothermic treatment and preparation method and application thereof
  • Material for tumor photothermic treatment and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Preparation of gold nanorods

[0091]Gold nanorods with LSPR absorption peak at 710nm prepared by silver ion-mediated seed growth method:

[0092] (1) Preparation of GNR material seed solution

[0093] Take 103 μL of chloroauric acid (1 mg / mL) and 0.5 mL of CTAB solution (0.2 mol / L) and mix well;

[0094] Add 100 μL of sodium borohydride solution (0.227 mg / mL) to the above solution under vigorous stirring, stir for 2 minutes, then stand at 30°C for 30 minutes, and set aside;

[0095] (2) Preparation of GNR material growth solution

[0096] Dissolve 1.8g CTAB and 0.22g 5-bromosalicylic acid in 95mL 50-70℃ ultrapure water, then add 1.2mL silver nitrate solution (4mM) to the solution, stir at 20-40℃, and then add to the solution After adding 2.06mL of chloroauric acid solution (10mg / mL), continue to stir for 15min, then add 400μL of ascorbic acid aqueous solution (0.064M), and stir vigorously until the solution becomes colorless;

[0097] (3) Preparation of GNR materia...

Embodiment 2

[0101] Preparation of gold nanorods

[0102] Silver ion-mediated seed growth method to prepare gold nanorods with LSPR absorption peak at 760nm:

[0103] (1) Preparation of GNR material seed solution

[0104] Take 103 μL of chloroauric acid (1 mg / mL) and 0.5 mL of CTAB solution (0.2 mol / L) and mix well;

[0105] Add 100 μL of sodium borohydride solution (0.227 mg / mL) to the above solution under vigorous stirring, stir for 2 minutes, then stand at 30°C for 30 minutes, and set aside;

[0106] (2) Preparation of GNR material growth solution

[0107] Dissolve 1.8g CTAB and 0.22g 5-bromosalicylic acid in 95mL 50-70℃ ultrapure water, then add 2.4mL silver nitrate solution (4mM) to the solution, stir at 20-40℃, and then add to the solution After adding 2.06mL of chloroauric acid solution (10mg / mL), continue to stir for 15min, then add 400μL of ascorbic acid aqueous solution (0.064M), and stir vigorously until the solution becomes colorless;

[0108] (3) Preparation of GNR materia...

Embodiment 3

[0112] Preparation of gold nanorods

[0113] Gold nanorods with LSPR absorption peak at 810nm prepared by silver ion-mediated seed growth method:

[0114] (1) Preparation of GNR material seed solution

[0115] Take 103 μL of chloroauric acid (1 mg / mL) and 0.5 mL of CTAB solution (0.2 mol / L) and mix well;

[0116] Add 100 μL of sodium borohydride solution (0.227 mg / mL) to the above solution under vigorous stirring, stir for 2 minutes, then stand at 30°C for 30 minutes, and set aside;

[0117] (2) Preparation of GNR material growth solution

[0118] Dissolve 1.8g CTAB and 0.22g 5-bromosalicylic acid in 95mL ultrapure water at 50-70℃, then add 2.4mL silver nitrate solution (4mM) and 1mL hydrochloric acid aqueous solution (1M) to the solution, 20-40 Stir at ℃, then add 2.06mL of chloroauric acid solution (10mg / mL) to the solution, continue to stir for 15min, then add 400μL of ascorbic acid aqueous solution (0.064M), and stir vigorously until the solution becomes colorless;

[...

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Abstract

The invention discloses preparation and application of a material for tumor photothermic treatment, and belongs to the field of biological medicine. The material comprises GNR, a mesoporous SiO2 layer wrapping the outer layer of the GNR, DOX loaded into pores of mesoporous SiO2, alkylation hydroxymethyl coumarin blocking mesoporous SiO2, and target hyaluronic acid on the outermost layer. After functional groups of the outer layer of SiO2 are modified into carboxyl groups, medicine loading is conducted through electrostatic interaction; after medicine loading, coumarin with alkyl chains are introduced through chemical grafting, an oily molecular layer is formed, and medicine leakage is prevented; in the material, ester bonds formed by coumarin molecules and the carboxyl groups on the surface of a silicon shell have light sensitivity, and the light response type intelligent release of medicine can be achieved; finally, molecules with long circulation and target molecules capable of being specifically combined with cancer cells are assembled on the material, and long circulation and dosage targeted performance are provided for the material.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a material, a preparation method and an application of photothermal therapy for tumors. Background technique [0002] Clinically, surgery, radiotherapy and chemotherapy together are called the three major treatment methods for cancer. Surgery is the main means of eradicating tumors, and long-term cure can often be achieved after surgical resection of earlier cancers. At present, due to the limitations of economy, culture and medical level, early diagnosis of cancer is still difficult, and 70%-80% of patients have exceeded the scope of radical surgical resection at the time of diagnosis. Radiation therapy treats tumors through radiation physical damage, and is also a local treatment; however, for most solid tumors, radiotherapy is still in the position of adjuvant therapy, and the side damage it produces not only causes pain to patients but also limits its application. At ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/04A61K47/22A61K47/36A61P35/00
CPCA61K31/704A61K41/0042A61K41/0052A61K47/02A61K47/22A61K47/36A61K2300/00
Inventor 孙宏浩王怡廖天作祝红达刘明星郭惠玲孙红梅
Owner HUBEI UNIV OF TECH
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