Method for preparing panax notoginseng total saponin freeze drying powder through convection heat transfer type freeze drying

A technology of total Panax notoginseng saponins and convective heat transfer, which is applied in the field of convective heat transfer freeze-drying to prepare total Panax notoginseng saponins freeze-dried powder or a composition thereof, and can solve the problem of long freeze-drying time of Panax notoginseng total saponins and high water content of products. , water-soluble and fat-soluble differences, etc., to achieve the effect of smooth sublimation, improved drying efficiency and stable quality

Inactive Publication Date: 2017-02-15
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the limitations of the existing freeze-drying process, the total freeze-drying time of Panax notoginseng saponins is longer, the water content of the product is higher, and there are great differences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Liquid preparation and pre-freezing: Dissolve the total saponins of Panax notoginseng in water, filter, pack the filtrate into open containers, place in a freeze-drying cabinet, keep cooling down to -5°C within 0.5h, and maintain at this temperature 0.5h;

[0033] 2) Freezing and system balance: After the pre-freezing is completed, continue to cool down within 0.5 hours, reduce the temperature of the plate layer in the freeze-drying cabinet to -25°C, and maintain it at -25°C for 0.5h, and then maintain the plate layer Keep the temperature constant, vacuumize and depressurize to 2Pa;

[0034] 3) Sublimation: Keep the temperature of the plate layer constant, and continuously pass into the cabinet the steam of 0.001 times the volume of the cavity in an instant, and the instantaneous pressure in the control cabinet rises to 100Pa for 0.5h; The incoming steam is replaced by anhydrous air, and the temperature of the inner plate layer of the freeze-drying cabinet is raised...

Embodiment 2

[0039] 1) Dosing and pre-freezing: Take total notoginseng saponins plus tert-butanol, dissolve them at 30°C to form a solution containing 2% of total notoginseng saponins, filter, pack the filtrate into open containers, and place in a freeze-drying cabinet Within 0.5h, continue to cool down to 0°C, and maintain at this temperature for 0.5h;

[0040] 2) Freezing and system balance: After the pre-freezing is completed, continue to cool down within 0.5h, reduce the temperature of the plate layer in the freeze-drying cabinet to -30°C, and maintain it at -30°C for 0.5h, and then maintain the plate layer Keep the temperature constant, vacuumize and depressurize to 5Pa;

[0041] 3) Sublimation: Keep the temperature of the plate layer constant, and intermittently pass into the cabinet an amount of steam that is 0.005 times the volume of the cavity in an instant, and the instantaneous pressure in the control cabinet rises to 150Pa for 0.5h; The incoming steam is replaced by anhydrous ...

Embodiment 3

[0046] 1) Dosing and pre-freezing: Take total notoginseng saponins and add glacial acetic acid, dissolve at 25°C to form a solution containing 4% of total notoginseng saponins, filter, pack the filtrate into open containers, and place in a freeze-drying cabinet , continue to cool down to -5°C within 3 hours, and maintain this temperature for 0.5 hours;

[0047] 2) Freezing and system balance: After pre-freezing, continue to cool down within 3 hours, reduce the temperature of the plate layer in the freeze-drying cabinet to -30°C, and maintain it at -30°C for 0.5h, and then maintain the plate layer temperature Unchanged, vacuumize and decompress to 10Pa;

[0048] 3) Sublimation: Keep the temperature of the plate layer constant, and continuously introduce steam of 0.01 times the volume of the cavity into the cabinet, and the instantaneous pressure in the control cabinet rises to 200Pa for 1 hour; The steam in the freeze-drying cabinet was replaced by anhydrous nitrogen, and the ...

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PUM

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Abstract

The present invention relates to a method for preparing panax notoginseng total saponin freeze drying powder through convection heat transfer type freeze drying. According to the present invention, by using the convection heat transfer type freeze drying preparation method of the panax notoginseng total saponin, drying is performed according to the predetermined freeze-drying process to obtain the freeze drying product of the panax notoginseng total saponin or the composition thereof, wherein the water content is extremely low, and the time for achieving the complete freeze-drying state is short.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to a method for preparing the freeze-dried powder of Panax notoginseng saponins or a composition thereof by convective heat transfer freeze-drying. Background technique [0002] During the freeze-drying process of materials, in order to allow solid water (ice) to sublimate continuously to form gas, the current general heating methods include volumetric heating and surface heating. Surface heating is divided into radiation heating and contact heating (conduction and convection). They realize the purpose of heat exchange through the heat radiation of the heating element or the heat conduction of the contact plate respectively. The freeze-drying method heated by convection has not been reported or applied at present. ; Volumetric heating refers to microwave heating at present, but there are not many large-scale applications in industrial production. [0003] Theoretically, the freeze...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K36/258F26B5/06
Inventor 黄宇声刘冠萍徐卓张栩颜陈勇贤英越陈苑君易燕群
Owner GUANGXI WUZHOU PHARMA GRP
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