Solid dispersion capsules for treating peptic ulcer
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for solid disperse capsules and peptic ulcers, which is applied in the direction of digestive system, capsule delivery, non-central analgesics, etc. It can solve the problems of large amount of medicinal materials, high cost, and many medicinal tastes, and achieves improved anti-ulcer activity and less side effects , ideal pain relief effect
Inactive Publication Date: 2017-02-15
门源县雪草木生物药业有限公司
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, the above-mentioned prescriptions have more medicina...
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0024] Example 1 Preparation of the pharmaceutical composition of the present invention
[0025] Zushi Ma 2g, Atractylodes 10g, Ganoderma lucidum 3g, Codonopsis 8g, Taizishen 8g, Yinchen 8g, Dandelion 10g, Platycodon 5g, Patchouli 5g, Nutmeg 4g; after drying, pulverize to 250 mesh, and mix well to obtain Raw material powder.
[0026] Take the raw medicine powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place it in a 0°C environment and quench it until it solidifies, and pulverize to get Solid dispersion.
[0027] The solid dispersion is encapsulated to obtain a solid dispersion capsule.
Embodiment 2
[0028] Example 2 Preparation of the pharmaceutical composition of the present invention
[0029] Zushi Ma 2g, Atractylodes 10g, Ganoderma lucidum 3g, Codonopsis 8g, Taizishen 8g, Yinchen 8g, Dandelion 10g, Platycodon 5g, Patchouli 5g, Nutmeg 4g; after drying, pulverize to 250 mesh, and mix well to obtain Raw material powder.
[0030] Take the raw medicine powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place it in a 0°C environment and quench it until it solidifies, and pulverize to get Solid dispersion.
[0031] The solid dispersion is mixed with appropriate microcrystalline cellulose and encapsulated to obtain solid dispersion capsules.
[0032] Typical case 1
[0033] Li Mou, male, 26 years old, has upper abdominal discomfort, belching, pantothenic acid, and occasional vomiting after eating. The symptoms have lasted for 2 months. After diagnosis, it was confirmed as chronic superficial gastri...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
Particle size
aaaaa
aaaaa
Login to view more
Abstract
The invention provides solid dispersion capsules for treating peptic ulcer. The solid dispersion capsules are prepared by putting solid dispersion in capsules, wherein the solid dispersion is prepared from the active pharmaceutical ingredient powder and polyethylene glycol-6000 in a weight ratio of (1-2) to (3-5); and the active pharmaceutical ingredient powder is prepared by grinding the following active pharmaceutical ingredients in parts by weight into 200-500 meshes: 1-3 parts of daphne giraldii nitsche, 7-13 parts of rhizoma atractylodis macrocephalae, 2-3 parts of lucid ganoderma, 5-10 parts of codonopsis pilosula, 5-10 parts of radix pseudostellariae, 5-10 parts of capillary artemisia, 5-10 parts of dandelions, 3-7 parts of platycodon grandiflorum, 3-7 parts of pogostemon cablin and 2-4 parts of nutmeg. According to the solid dispersion capsules, the active pharmaceutical ingredient powder is made into solid dispersion capsules, the bioavailability of the medicines is improved, and the anti-ulcer activity is obviously improved. However, the main defect of solid dispersion is that the solid dispersion is easily oxidized and aged in the storage process and consequently the dissolving speed is reduced. Therefore, by preparing the solid dispersion into the capsules, direct contact between air and the solid dispersion is avoided through capsule shells, and the aging is delayed.
Description
technical field [0001] The present invention relates to a solid dispersion capsule for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to the localized circular or oval full-thickness defects of the gastric and duodenal mucosa. The muscularis mucosa is penetrated, and fibrous scars are inevitably left after healing, and the surface is a layer of epithelium. Covered, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it is believed that the formation of ulcers also has an important relationship with the infection of Helicobacter pylori in the stomach. [0003] Chronic superficial gastritis is a chronic superficial inflammation of the gastric mucosa, which is a common disease of the digestive system and is a type of chronic gastritis. It can be caused by alcoholism...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more