Preparation method of fenbendazole which is benzimidazole anti-helminthic drug

A technology of medicine benthiimazole and benzimidazole, which is applied in the field of preparation of antiparasitic raw material benthiimazole, can solve the problems of difficult operation, high cost, large environmental impact and the like, and achieves the effect of safe operation
CN106397334AInactive Publication Date: 2017-02-15JIANGSU BAOZONG & BAODA PHARMACHEM
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU BAOZONG & BAODA PHARMACHEM
Publication Date
2017-02-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of fenbendazole which is a benzimidazole anti-helminthic drug. Fenbendazole is obtained by taking p-dichlorobenzene as a raw material through nitration, amination, condensation, reduction and ring-closure, and the final product content is 98-101%. The preparation method is simple and efficient, is safe to operate, and is suitable for industrial production.
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Description

Technical field

[0001] The invention relates to a new method for preparing a benzimidazole anthelmintic, in particular to a new method for preparing an anti-parasitic raw material medicine Fenzimidazole.

[0002] 2. Background technology

[0003] Fenbendazole, also known as fenbendazole, is chemically named 5-phenylthiobenzimidazole-2-methyl carbamate. It is a broad-spectrum and highly effective antiparasitic drug for veterinary use. Fenzimidazole is used to repel animal gastrointestinal parasites. It not only has high anthelmintic activity against animal gastrointestinal roundworms, hookworms, whipworms, some tapeworms and strongyloides, but also against some bronchial tree and lung parasites. (Cat lungworm and lung fluke) also have better effects. Fenzimidazole has the advantages of wide anthelmintic spectrum, low toxicity, good tolerance, wide safety range, and good palatability.

[0004] Fenthiamidazole was first developed by Hoechst in the 1970s. The synthetic routes reported...

Claims

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