Compositions and methods for the treatment and prevention of antipsychotic medication-induced weight gain

一种抗精神病药物、药物的技术，应用在精神病学领域，能够解决AIWG影响尚未被研究等问题

Inactive Publication Date: 2017-02-22
CENT FOR ADDICTION & MENTAL HEALTH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of genetic variation in the orexin system on AIWG has not been studied so far

Method used

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  • Compositions and methods for the treatment and prevention of antipsychotic medication-induced weight gain
  • Compositions and methods for the treatment and prevention of antipsychotic medication-induced weight gain
  • Compositions and methods for the treatment and prevention of antipsychotic medication-induced weight gain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0144] 1. Genetic markers near GCG

[0145] A total of N=128 subjects with schizophrenia or schizoaffective disorder were included in the study (see Tiwari et al.2010; Tiwari et al.2010; Brandl et al.2012; Brandl et al.2013; Tiwari et al.2013 ). Diagnosis is made according to DSM-III-R or DSM-IV criteria. Subjects were recruited from two different sites: Sample A (N=74; HYM) was collected at Case Western Reserve University, Cleveland, Ohio, USA. The patient was naïve to second-generation antipsychotics and received clozapine for six weeks. Sample B (N=54; JAL) was collected at Hillside Hospital, Glen Oaks, NY, USA. Patients were treated with clozapine, risperidone, olanzapine, or halopirol using a double-blind study design. Written informed consent was obtained from all subjects according to institutional ethical guidelines prior to study entry. Detailed demographic and clinical characteristics are provided in Table 5 and have been published previously (Tiwari et al. 20...

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PUM

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Abstract

The invention provides methods and compositions for the treatment of a subject having a psychiatric disease or disorder based upon the subject's genotype and / or the number of risk alleles carried by the subject, which risk alleles have been found by the present inventors to predispose a subject to antipsychotic medication induced weight gain (AIWG). The methods of the invention also provide for different treatments, or different treatment regimens, for the subject depending on the subject's risk of AIWG. Related compositions, in the form of kits, systems, and computer-readable media are also provided.

Description

[0001] field of invention [0002] The present invention relates to the field of psychiatry. In particular, the present invention relates to methods and compositions for treating and preventing antipsychotic drug-induced weight gain based on one or more genetic polymorphisms associated with antipsychotic drug-induced weight gain in human subjects . [0003] Background of the invention [0004] Antipsychotic drugs are widely used to treat psychiatric disorders, including schizophrenia, mood, bipolar disorder, and autism. Most second-generation antipsychotics have been associated with substantial weight gain and metabolic disturbances, which increase the risk of early death (Lencz and Malhotra, 2009; Muller and Kennedy, 2006). The high prevalence of more than 30% of treated individuals showing significant weight gain makes these side effects one of the causes of patient non-compliance, which increases treatment costs. Currently there are no available biomarkers for antipsychot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/12C12Q1/68G01N33/50G06F19/10G06F19/18G16B20/00
CPCG01N33/5091C12Q2600/106C12Q2600/156G16B20/00C12Q1/6883A61K31/445A61K31/519G16B20/20
Inventor A·K·蒂瓦里E·J·布兰德N·I·乔杜里V·F·贡萨尔维斯J·G·宝盖特J·L·肯尼迪D·J·穆勒C·C·载
Owner CENT FOR ADDICTION & MENTAL HEALTH
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