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A vitamin C plus zinc sustained-release pellet preparation and preparation method thereof
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A technology for sustained-release pellets and vitamins, which is applied in microcapsules, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of difficult sustained-release dosage forms, hinder the formation of pellets, etc. The effect of high production cost and large production capacity
Active Publication Date: 2019-01-22
JIANGSU ALAND NOURISHMENT
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Problems solved by technology
[0015] However, compared with conventional dosage forms, sustained-release dosage forms are relatively difficult to operate and control. For tablet technology, it is easier to implement. Adjusting the type and amount of sustained-release materials is difficult for pellets, because sustained-release The materials are basically very viscous materials, which hinder the formation of the pellets during the formation of the pellets. In the prior art, for the sustained-release preparations with high vitamin C content of 60%, the release rate reaches 4 hours ≤ 60 %, ≥75% sustained-release pellets in 8 hours, according to domestic literature, there is no information related to the production of this product
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Embodiment 1
[0036] Prescription of the present invention comprises the component shown in table 1:
[0037] Table 1
[0038]
[0039] A preparation method of vitamin C plus zinc sustained-release pellet preparation comprises the following steps:
[0040] 1. Weigh out the sodium carboxymethylcellulose in the formula to make a 1% concentration slurry;
[0041] 2. Weigh the ingredients according to the formula, divide them into one, two, and three piles according to Table 1, and pile them up for later use;
[0042] 3. Put the first batch of vitamin C (VC), calcium phosphate and zinc oxide materials into the wet mixing granulation pot for mixing, add 1% concentration of 90% sodium carboxymethyl cellulose slurry, stir and granulate, and make soft material;
[0043] 4. The obtained soft material is produced into wet granules with a swing granulator equipped with a 20-mesh screen;
[0044] 5. Put the wet granules into the wet granulation pot, turn on the equipment, and at the same time, d...
Embodiment 2
[0054] Prescription of the present invention comprises the component shown in table 3:
[0055] table 3
[0056]
[0057] The same process steps as in Example 1 were used to obtain the finished micropills, which were filled into 850 mg / granule with 00# lengthened gelatin capsule shells, passed the test, and the dissolution data after 4 hours and 8 hours were shown in Table 4:
[0058] Table 4
[0059]
[0060] From the data point of view, each capsule meets the quality requirements of ≤60% in 4 hours and ≥75% in 8 hours.
Embodiment 3
[0062] Prescription of the present invention comprises the component shown in table 5:
[0063] table 5
[0064]
[0065]The process operation steps of Example 1 are the same, and the finished micropills obtained are filled into 850 mg / granule with 00# lengthened gelatin capsule shells. After passing the test, the dissolution data after 4 hours and 8 hours are shown in Table 6:
[0066] Table 6
[0067]
[0068] From the data point of view, each capsule meets the quality requirements of ≤60% in 4 hours and ≥75% in 8 hours.
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Abstract
The invention provides a VC zinc-added sustained-release pellet preparation and a preparation method of the VC zinc-added sustained-release pellet preparation. The VC zinc-added sustained-release pellet preparation comprises the following components: VC, calcium phosphate, zinc, maltodextrin, povidone K30, sodium carboxymethyl cellulose, vegetable oil, a colorant and stearic acid. According to the invention, sustained-release materials are selected to continuously test an optimum formula and process, and a preparation technology of the conventional wet granulation equipment is used, so that the problem of high production cost of the original formulation is solved, furthermore, the technology for preparing high-quality pellets by the common equipment is provided. The invention provides the VC pellet preparation with a sustained-release function, creates an effective sustained-release material, and provides the method for preparing the pellets by a simple and convenient wet granulation way. In addition, the method is the pellet preparation method which is strong in operability, large in capacity, good in curative effect and lower in manufacturing cost.
Description
technical field [0001] The invention belongs to the technical field of biology and new medicine, and in particular relates to a vitamin C-added zinc sustained-release pellet preparation and a preparation method thereof. Background technique [0002] Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. Of all the vitamins, vitamin C is the most unstable. [0003] Most animals can synthesize vitamin C by themselves, but humans, apes, guinea pigs, etc. must ingest it from food; vitamin C plays an important role in the formation of collagen. Collagen is an important substance for the development and repair of human tissue cells, gums, blood vessels, bones, and teeth; it helps the body absorb iron; it accelerates the consumption of vitamin C in a state of tension. Vitamin C participates in the oxidation-reduction process in the body, promotes the growth and development of the human body, enhances the body's resistance to diseases, promotes the formation of collag...
Claims
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