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Separation process of high-purity alpha-linolenic acid

A linolenic acid, high-purity technology, applied in the field of high-purity α-linolenic acid separation technology, can solve the problems of unfavorable industrialization, high temperature environment, and high cost

Inactive Publication Date: 2017-03-15
烟台燕园科玛健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention patent applied by the applicant Yantai Yanyuan Kema Biotechnology Development Co., Ltd.: a method of extracting and purifying α-linolenic acid, which discloses the traditional three-stage molecular distillation method. The disadvantage of this method is that it requires a high temperature environment. First, the cost is high. , the second is not conducive to industrialization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Dissolve 5 g of urea in a water-containing 10% ethanol solution, add 5 g of silica gel, and evaporate to dryness under reduced pressure to obtain a stationary phase; the stationary phase is packed into a column, and then the crude α-linolenic acid is loaded into a column, and the The ethanol solution was used as the mobile phase, injected into the chromatography column at a uniform speed for elution, and the eluted fractions of different periods were collected, combined and evaporated to dryness to obtain α-linolenic acid with a purity of 99%.

Embodiment 2

[0017] Dissolve 5 g of urea in water-containing 10% ethanol solution, add 1 g of silica gel, and evaporate to dryness under reduced pressure to obtain a stationary phase; the stationary phase is packed into a column, and then the crude α-linolenic acid is loaded into a column, and the The ethanol solution was used as the mobile phase, injected into the chromatography column at a uniform speed for elution, and the eluted fractions of different periods were collected, combined and evaporated to dryness to obtain α-linolenic acid with a purity of 99%.

Embodiment 3

[0019] Dissolve 5 g of urea in a water-containing 10% ethanol solution, add 4 g of silica gel, and evaporate to dryness under reduced pressure to obtain a stationary phase; the stationary phase is packed into a column, and then the crude α-linolenic acid is loaded into a column, and the column containing 12.5 wt % ethyl acetate is obtained. The ethanol solution was used as the mobile phase, injected into the chromatography column at a uniform speed for elution, and the eluents of different periods were collected, combined and evaporated to dryness to obtain α-linolenic acid with a purity of 99%.

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Abstract

The invention relates to a separation process of high-purity alpha-linolenic acid. The separation process comprises the following steps: dissolving urea into an ethanol solvent, adding silica gel, loading the silica gel with the urea, and removing ethanol, so as to obtain a fixed phase, wherein the mass ratio of the urea to a carrier is (1-5) to 1; and packing a column with the prepared fixed phase, charging the column with rough alpha-linolenic acid, injecting a flowing phase into a chromatographic column at a constant speed, collecting eluted components at different stages, combining the collected eluted components, and drying by distillation so as to obtain alpha-linolenic acid with a purity of 99%, wherein the flowing phase is an ethyl acetate-ethanol solution, and the mass ratio of ethyl acetate to ethanol is (1-2) to 10. The separation process has the beneficial effects that the urea is dissolved in alcohol and is complexed to the silica gel to form a stable content, the stable content is used as the chromatographic column, fatty acids with a similar molecular formula are effectively separated by virtue of a column chromatography principle, the condition that a high-temperature environment is required by molecular distillation is changed, and the operation can be carried out at the normal temperature.

Description

technical field [0001] The invention relates to a high-purity α-linolenic acid separation process. Background technique [0002] In the prior art, there are various methods for separating and purifying α-linolenic acid. The most commonly used method is molecular distillation technology. It is necessary to investigate the influence of operational factors such as optimization of distillation temperature and system pressure on the purity of α-linolenic acid. The invention patent applied by the applicant Yantai Yanyuan Kema Biotechnology Development Co., Ltd.: a method of extracting and purifying α-linolenic acid, which discloses the traditional three-stage molecular distillation method. The disadvantage of this method is that it requires a high temperature environment. First, the cost is high. , the second is not conducive to industrialization. [0003] Therefore, it is necessary to propose an effective technical solution to solve the above problems. Contents of the inventio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C51/47C07C57/12
CPCC07C51/42C07C51/47
Inventor 陈学沛荣艳红张秋红
Owner 烟台燕园科玛健康产业有限公司