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Preparation method for gamma-cyclodextrin

A technology of cyclodextrin and temperature control, which is applied in the field of preparation of γ-cyclodextrin, can solve the problems of limited promotion, small yield and small production scale, and achieves the effect of high yield

Inactive Publication Date: 2017-03-15
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the application prospect of γ-cyclodextrin is wider than that of β-cyclodextrin. However, there are currently factories producing γ-cyclodextrin. Due to the small production scale and low yield, the price is relatively high, which limits the application. to promote

Method used

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  • Preparation method for gamma-cyclodextrin
  • Preparation method for gamma-cyclodextrin
  • Preparation method for gamma-cyclodextrin

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Experimental program
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Effect test

Embodiment 1

[0014] The concentration of β-CD is 19mmol / L, adjust its pH value to 7.0 with ammonia water, and add cyclodextrin glycosyltransferase and glycyrrhizic acid to β-cyclodextrin at a temperature of 64°C. When the addition amount of glycyrrhizic acid is 390U / g and 2.9% of the mass of the whole reaction solution, the conversion rate of γ-CD can reach 31% if the reaction is continued for 26 hours.

Embodiment 2

[0016] The concentration of β-CD is 21mmol / L, adjust the pH value to 6.8 with ammonia water, and add cyclodextrin glycosyltransferase and glycyrrhizic acid to β-cyclodextrin at a temperature of 63°C. 400U / g, when the addition amount of glycyrrhizic acid is 3% of the mass of the whole reaction solution, the reaction lasts for 27 hours, and the conversion rate of γ-CD can reach 32%.

Embodiment 3

[0018] The concentration of β-CD is 20mmol / L, adjust its pH value to 7.1 with ammonia water, and add cyclodextrin glycosyltransferase and glycyrrhizic acid to β-cyclodextrin at a temperature of 65°C. When the added amount of glycyrrhizic acid is 410U / g and 3.1% of the mass of the whole reaction solution, the conversion rate of γ-CD can reach 32.5% if the reaction is continued for 25 hours.

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Abstract

The invention specifically relates to a preparation method for gamma-cyclodextrin, belonging to the technical field of materials. The preparation method comprises the following steps: adjusting the pH value of beta-cyclodextrin to 6.8 to 7.2 with ammonia water, controlling temperature to be 62 to 66 DEG C, adding cyclodextrin glycosyltransferase and glycyrrhizic acid into beta-cyclodextrin and carrying out a reaction for 25 to 29 h so as to obtain gamma-cyclodextrin. According to the invention, beta-cyclodextrin is converted into gamma-cyclodextrin in virtue of cyclodextrin glycosyltransferase under specific conditions. The special stereochemical structure of gamma-cyclodextrin enables gamma-cyclodextrin to form complexes with a great number of compounds. Substances with poor water solubility or groups thereof can be enveloped in the holes of cyclodextrin, so dissolvability or stability of molecules is improved. The preparation method provided by the invention is high in yield, and prepared gamma-cyclodextrin is extensively applied to fields like medicine, health food, agricultural products and daily chemicals.

Description

technical field [0001] The invention belongs to the technical field of materials, in particular to a preparation method of gamma-cyclodextrin. Background technique [0002] β-cyclodextrin, also known as cyclomaltoheptaose, cycloheptadextrin, referred to as β-CD, is made from starch extracted by microbial enzymes, and is composed of 7 glucose residues and β-1,4-glycosidic bonds. Combined to form a ring, the relative molecular mass is 1135. β-cyclodextrin can form inclusion complexes with a variety of compounds to stabilize, solubilize, slow-release, emulsify, resist oxidation, resist decomposition, keep warm, prevent moisture, and have the effect of masking odors. It is a new type of molecular encapsulation Material. [0003] As a new inclusion material, β-cyclodextrin has great application value and potential. The main molecular configuration of β-cyclodextrin is like a hollow conical cylinder with a wide top and a narrow bottom, open at both ends. In view of this unique ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/18C12P19/04
CPCC12P19/18C12P19/04
Inventor 曹新志
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING