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A kind of preparation method and application of sedum notoginseng polysaccharide

A technology for sedum notoginseng and polysaccharide is applied in the field of preparation of sedum notoginseng polysaccharide, and achieves the effects of simple preparation process, significant economic and social benefits, and easy operation.

Inactive Publication Date: 2018-10-09
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a preparation method of Sedum notoginseng polysaccharide and its application, which can effectively solve the problem of extracting and purifying polysaccharides from Sedum notoginseng medicinal materials and preparing anti-inflammatory drugs. Problems with Breast Cancer Drugs

Method used

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  • A kind of preparation method and application of sedum notoginseng polysaccharide
  • A kind of preparation method and application of sedum notoginseng polysaccharide

Examples

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Effect test

Embodiment 1

[0010] A preparation method of Sedum notoginseng polysaccharide, including the following steps:

[0011] Take 125g crude powder of Panax notoginseng medicinal material, each time use 95% ethanol (ie 875ml) which is 7 times the weight of crude powder of medicinal material, and extract 2 times under reflux at 90℃, the first extraction time is 1.5h, the second time The extraction time is 1h. The drug residue is filtered and dried in a ventilated place. Add 8 times the weight of the crude medicinal material to the drug residue each time (ie 1000ml), and then reflux and extract 3 times at 95℃. The time is 2h, 1.5h, 1h, filter, combine the filtrate, concentrate to a relative density of 1.1, adjust to 75% alcohol content with 95% ethanol by volume, stand for 24h, centrifuge at 13000r / min for 10min to get the precipitate, The precipitate was washed with the same weight of absolute ethanol, acetone, and diethyl ether with the same weight as the crude powder of the medicinal materials, and...

Embodiment 2

[0013] A preparation method of Sedum notoginseng polysaccharide, including the following steps:

[0014] Take a view of 1250g of Panax notoginseng crude powder, each time use 95% ethanol (ie 8750ml) with a volume concentration of 7 times the weight of the crude powder, and extract twice at 95℃ under reflux, the first extraction time is 1.5h, the second The extraction time is 1h, the medicine residue is filtered, and the medicine residue is placed in a ventilated place to dry. Add 12 times the weight of the crude medicinal material (15000ml) to the medicine residue each time, and then reflux and extract 3 times at 98°C. Time is 2h, 1.5h, 1h, filter, combine the filtrate, concentrate to relative density 1.2, adjust to 85% alcohol content with 95% ethanol, stand for 24h, centrifuge at 13000r / min for 10min to get the precipitate, The precipitate was washed with the same weight of absolute ethanol, acetone, and ether twice as the crude powder of medicinal materials in turn to obtain c...

Embodiment 3

[0016] A preparation method of Sedum notoginseng polysaccharide, including the following steps:

[0017] Take 250g of crude powder of Panax notoginseng medicinal material, each time use 95% ethanol (1500ml) with a volume concentration of 6 times the weight of crude medicinal material, and extract at 92℃ under reflux for 2 times. Extraction time is 1.5h and 1h respectively. The medicine is obtained by filtration. Dry the dregs in a ventilated place, add 10 times the weight of the crude medicinal material to the slag each time (2500ml), and then reflux and extract 3 times at 97℃. The extraction time is 2h, 1.5h, 1h, filter, combine the filtrate, concentrate to a relative density of 1.1, adjust to 80% alcohol content with 95% ethanol by volume, stand for 24h, centrifuge at 13000r / min for 10min to get the precipitate, and use the same as the crude powder of medicinal materials in turn Wash the weight of anhydrous ethanol, acetone, and ether twice to obtain crude polysaccharides. The ...

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Abstract

The invention relates to a method of preparing sedum aizoon L. polysaccharides and applications of the polysaccharides, and effectively overcomes the issue of preparing polysaccharides through extracting sedum aizoon L. that is a medical material and purifying and the issue of preparing a medicine resisting breast cancer. The method includes subjecting sedum aizoon L. medicine crude powder to reflux extraction with ethanol, performing concentration and centrifugation to obtain a precipitate, washing the precipitate with absolute ethanol, acetone and ethyl ether respectively with the weights of the absolute ethanol, the acetone and the ethyl ether are same as the weight of the medicine crude powder, adding water for dissolution, then adding a trichloroacetic acid solution, stirring the mixture, centrifuging the mixture to obtain a supernatant liquid, performing dialysis with water, performing vacuum concentration, performing centrifugation to obtain a precipitate, and washing the precipitate with absolute ethanol, acetone and ethyl ether respectively for two times to obtain the sedum aizoon L. polysaccharides, with the weights of the absolute ethanol, the acetone and the ethyl ether are same as the weight of the medicine crude powder. The method is simple in process, easy in operation and low in cost, and has a prospect of preparation of medicines resisting breast cancer clinically. The application in the field of medicines resisting breast cancer is achieved. Application value of the sedum aizoon L. medicine material is exploited. Economic benefit and social benefit are significant.

Description

Technical field [0001] The invention relates to the field of Chinese medicine pharmacy, in particular to a preparation method and application of sedum notoginseng polysaccharide. Background technique [0002] Polysaccharides are a type of high molecular compound composed of monosaccharides. As one of the components of life substances, in addition to storing energy and supporting structures, polysaccharides are also an important type of information molecules, which are widely involved in various life phenomena and physiological processes of cells. The regulation of immune cells, such as the transmission and perception of information between immune cells, cell transformation, division, and regeneration. In recent years, people have discovered that some polysaccharides, such as lentinan, Yunzhi polysaccharide, and Poria polysaccharide, can treat some diseases caused by damage to the immune system without toxic side effects. As an adjuvant therapy for cancer, it has the advantages o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P35/00
CPCA61K31/715A61K36/41C08B37/0003
Inventor 王俊敏刘富岗时博司金光孙彦君冯卫生郝志友万焱高美玲付露陈辉张艳丽
Owner HENAN UNIV OF CHINESE MEDICINE