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Applications of carboxymethyl chitosan to preparation or screening of products for antiallergic treatment

A carboxymethyl chitosan, anti-allergic technology, applied in allergic diseases, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of undisclosed anti-allergic and other problems

Active Publication Date: 2017-04-26
SHANGHAI TAO SHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It is disclosed in the prior art that carboxymethyl chitosan has the purposes of moisture absorption, moisturizing and antibacterial, but it does not disclose that it has anti-allergic purposes

Method used

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  • Applications of carboxymethyl chitosan to preparation or screening of products for antiallergic treatment
  • Applications of carboxymethyl chitosan to preparation or screening of products for antiallergic treatment
  • Applications of carboxymethyl chitosan to preparation or screening of products for antiallergic treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In this embodiment, carboxymethyl chitosan with a number average molecular weight of 2000 was prepared.

[0025] The carboxymethyl chitosan raw material with higher viscosity-average molecular weight is degraded with hydrogen peroxide, the viscosity-average molecular weight of the carboxymethyl chitosan raw material with higher viscosity-average molecular weight is 30W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0026] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher viscosity-average molecular weight under stirring conditions for degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.2 until the viscosity of the reaction system is At 80cp, sodium sulfite was added to stop the reaction. In the degradation rea...

Embodiment 2

[0029] Carboxymethyl chitosan with a number average molecular weight of 8000 was adopted in the present embodiment.

[0030] The carboxymethyl chitosan raw material with higher viscosity-average molecular weight is degraded with hydrogen peroxide, the viscosity-average molecular weight of the carboxymethyl chitosan raw material with higher viscosity-average molecular weight is 40W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0031] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher viscosity-average molecular weight under stirring conditions for degradation reaction, adding alkali in the degradation reaction process so that the pH of the reaction system is 8.5, until the viscosity of the reaction system is At 110cp, sodium sulfite was added to stop the reaction. In the degr...

Embodiment 3

[0034] Carboxymethyl chitosan with a number average molecular weight of 15,000 is used in this embodiment.

[0035] The carboxymethyl chitosan raw material with higher viscosity average molecular weight is degraded with hydrogen peroxide, the viscosity average molecular weight of the higher carboxymethyl chitosan raw material with viscosity average molecular weight is 55W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0036] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher viscosity-average molecular weight under stirring conditions for degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.2 until the viscosity of the reaction system is Add sodium sulfite at 120cp to stop the reaction. In the degradation reaction, the r...

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PUM

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Abstract

The invention discloses applications of carboxymethyl chitosan to preparation or screening of products for antiallergic treatment. Cells and human body tests show that carboxymethyl chitosan has antiallergic efficacy and can be used as an antiallergic active component which is added into the product with practical application values.

Description

technical field [0001] The invention relates to a new application of carboxymethyl chitosan, in particular to the application of carboxymethyl chitosan in preparing or screening products for treating allergies. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial, fresh-keeping effect, and an amphoteric polyelectrolyte. It has many applications in cosmetics, fresh-keeping, medicine, etc. It is also one of the chitosan derivatives that have been studied more in recent years. [0003] The carboxymethyl group of carboxymethyl chitin is substituted on the C6-OH of the sugar residue, and a small amount of carboxymethyl group is substituted on the C3-OH, resulting in O-carboxymethyl chitin. In chitosan, the carboxymethyl group will be substituted on both -OH and -NH to generate O-carboxymethyl and N-carboxymethyl chitosan. The actual substitutions are: C6 -O-carboxymethyl, C2-N-carboxymethy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P37/08
CPCA61K31/722
Inventor 肖璠徐宇帆徐耀中李萍姜义华金莎徐娅
Owner SHANGHAI TAO SHENG BIOTECH CO LTD
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