Polymorphic substances of triaryl dimethyl piperazine hydrobromide, and preparation method and application thereof

A technology of dimethylpiperazine and ketone hydrobromide, applied in the field of medicine, can solve problems such as inability to concentrate, sexual dysfunction, long onset time, and confusion of thinking, and achieve the prevention and treatment of depression and other potential diseases, good stability and high bioavailability
CN106588876AInactive Publication Date: 2017-04-26YUNNAN INST OF MATERIA MEDICA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YUNNAN INST OF MATERIA MEDICA
Publication Date
2017-04-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses two polymorphic substances A and B of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxylbenzyl)methyl)phenyl)(4-methylpiperidine-1-yl)ketone hydrobromide; and a preparation method and an application thereof in the preparation of drugs for preventing or treating mood disorder or diseases related with a delta opioid receptor.
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Description

technical field

[0001] The present invention relates to, but not limited to, the technical field of medicine, in particular, relates to but not limited to a triaryl dimethyl piperazine hydrobromide multi-crystal form and its preparation method and application. Background technique

[0002] Depression is a common mental illness, mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, worry that you have various diseases, and feeling that you are suffering from various diseases in your body. Discomfort, and in severe cases, suicidal thoughts and behaviors may appear. In the fourth edition of the "Diagnostic and Statistical Manual of Mental Disorders" published by the American Psychiatric Association, depression is classified under mood disorders and is divided into three types: major depressive disorder, dysthymic disorder and other Unspecified depression.

[0003] Factors causing depression include: gen...

Claims

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