A kind of anti-alcoholic and liver-protecting composition and its preparation method and application

A technology for detoxifying and protecting the liver and a composition, applied in the directions of application, drug combination, pharmaceutical formulation, etc., can solve the problem of alcoholic liver injury without a definite curative effect, etc., and achieves improved stability and solubility, improved stability, and improved preparation technology. simple effect

Active Publication Date: 2021-05-18
NINGBO YUFANGTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, the best-selling hangover products in Europe, America and Japan are mostly added with stimulants, analgesics, vitamins and minerals, which can only temporarily relieve hangover symptoms and have no definite effect on alcoholic liver damage

Method used

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  • A kind of anti-alcoholic and liver-protecting composition and its preparation method and application
  • A kind of anti-alcoholic and liver-protecting composition and its preparation method and application
  • A kind of anti-alcoholic and liver-protecting composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation of corn oligopeptide

[0052] The preparation method of the corn oligopeptide is as follows: the corn gluten powder is pulverized, enzymatically hydrolyzed, filtered and dried to obtain the required corn oligopeptide powder. The specific process is as follows:

[0053] (1) Pulverization: crush corn gluten powder, pass through a 60-mesh sieve, and prepare a corn gluten dispersion with purified water.

[0054] (2) Enzymolysis: adjust the pH of the zein dispersion to 8-9, heat to 45°C and keep the temperature between 45±5°C, then add neutral protease and papain to the zein dispersion, Stir evenly and enzymolyze for 2h to 3h, wherein the addition of neutral protease is 0.2% to 0.5% of the substrate content, and the addition of papain is 0.1% to 0.2% of the substrate content. Enzyme inactivation.

[0055] (3) Filtration: The enzymolysis liquid after deactivating the enzyme is centrifuged through a centrifuge (4000rpm, 15min) to remove impurit...

Embodiment 2

[0072] Embodiment 2: the preparation of curcumin microcapsule

[0073] Carry out microencapsulation treatment to curcumin among the present invention, and the selection of wall material and the selection of core material in microencapsulation treatment are key, specifically as follows:

[0074] 2.1 Selection of wall materials

[0075] The spray drying O / W emulsion system has various requirements for the embedding of hydrophobic core materials. Traditional wall materials such as gum arabic and maltodextrin lack emulsification and film-forming properties and cannot be used as wall materials alone. Milk proteins, including Although whey protein, casein itself and its mixture of different sugars show good embedding properties, their high cost limits market consumption. In summary, the present invention selects gum arabic and soybean protein isolate as wall materials.

[0076] 2.1 Selection of core material

[0077] Phospholipid complex is a novel microcapsule technology. After ...

Embodiment 3

[0092] Example 3: Preparation of Hovenia dulcis Fructus Extract

[0093] The medicinal material extraction of the present invention adopts dynamic countercurrent extraction technology, and dynamic countercurrent extraction (Dynamic Countercurrent Extraction, DCE) refers to a method in which the medicinal material and the solvent move in opposite directions in the leaching container to continuously and fully perform contact extraction. Countercurrent extraction can make full use of the concentration gradient of the solid-liquid two-phase, and gradually diffuse the active ingredients into the extraction solution with a lower initial concentration, so that the extracted extraction solution can reach a higher equilibrium concentration, which can ensure the extraction of the extracted material. It can save energy, shorten the extraction time, and greatly reduce the workload and energy consumption of the subsequent concentration process. It can comprehensively solve the problems exis...

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Abstract

The invention relates to a composition for anti-alcoholism and liver protection, which comprises the following components and their mass parts: 20-50 parts of corn oligopeptide powder, 5-20 parts of curcumin microcapsules, 3-15 parts of Hovenia dulcis fruit extract 3 to 15 parts of Dendrobium officinale extract, 0 to 10 parts of kudzu root extract, 0 to 10 parts of amomum extract, 0 to 10 parts of acerola cherry powder, and 0 to 10 parts of selenium-enriched yeast; it also involves the combination Preparation methods and applications of substances. The curcumin used in the present invention adopts microcapsule embedding technology, which not only improves its stability, but also improves its bioavailability, and the corn oligopeptide, curcumin microcapsule and other various components are rationally combined, so that It plays the role of joint hangover and liver protection, overcomes the problems of single function and poor efficacy of existing products, can effectively promote the body's ability to metabolize alcohol, reduce the toxicity of alcohol to the liver, and effectively improve the effects of alcohol understanding and liver protection. In addition, the preparation process is simple, the active ingredients of the raw materials can be extracted to the greatest extent, and the bioavailability and efficacy of the active ingredients can be improved.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a composition for relieving alcohol and protecting the liver, its preparation method and application. Background technique [0002] With the improvement of people's living standards and the acceleration of the pace of life, the number of drinking people is also increasing. Among the drinking people, there are many senior business people and managers, regardless of age and gender. Symptoms such as dizziness, memory loss, and gastrointestinal discomfort will appear after drinking, and long-term heavy drinking can lead to alcoholic liver disease. In addition, modern people are under high work pressure and often stay up late to work overtime, which can easily lead to insufficient liver blood and uncontrollable fatigue, a sub-health state that cannot be relieved by rest. [0003] The functions of the liver are complex and diverse, and it occupies a very important position in the body's s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/01A61K9/50A61P39/02A61P1/16A23L33/105A23L33/10A23L33/18A23L33/14A61K36/9064A61K31/12
CPCA23V2002/00A61K9/5052A61K31/12A61K36/064A61K36/488A61K36/72A61K36/736A61K36/8984A61K36/9064A61K38/011A61K2236/331A61K2300/00A23V2200/334A23V2250/21A23V2250/76
Inventor 贾福怀涂宏建王俊陶刚袁媛王彩霞熊菲菲许璐云戴飞
Owner NINGBO YUFANGTANG BIOTECH
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