An inert cycloalkane c(sp 3 )-h bond functionalization method
A cycloalkane, functionalization technology, applied in organic chemistry, oxidation to prepare carbonyl compounds, condensation to prepare carbonyl compounds, etc., can solve the problem of difficult metal atom orbital interaction, etc., and achieve mild reaction conditions, low price, and high yield. Effect
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Embodiment 13
[0032]
[0033] Add 41.6mg (0.4mmol) of styrene, 5.1mg (0.04mmol) of ferrous chloride, 144.0mg (1.6mmol) of tert-butanol peroxide, 110.4mg (0.8mmol) of potassium carbonate, and cyclic Heptane (2 mL), and the reaction flask was stirred at 100° C. for 24 h. After the reaction was completed, the reaction solution was filtered through a glass dropper containing silica gel, rinsed with ethyl acetate, the filtrate was spin-dried, and separated by column chromatography to obtain the target product, a colorless oily liquid, with a yield of 61%.
Embodiment 14
[0035]
[0036] Add 55.2 mg (0.4 mmol) of p-chlorostyrene, 5.1 mg (0.04 mmol) of ferrous chloride, 144.0 mg (1.6 mmol) of tert-butanol peroxide, and 110.4 mg (0.8 mmol) of potassium carbonate into a dry 10 mL schlenk bottle , cyclohexane (2mL), and the reaction bottle was stirred at 100°C for 24h. After the reaction was completed, the reaction solution was filtered through a glass dropper containing silica gel, rinsed with ethyl acetate, the filtrate was spin-dried, and separated by column chromatography to obtain the target product, a colorless oily liquid, with a yield of 71%.
Embodiment 15
[0038]
[0039] Add 53.6 mg (0.4 mmol) of p-methoxystyrene, 5.1 mg (0.04 mmol) of ferrous chloride, 144.0 mg (1.6 mmol) of tert-butanol peroxide, and 110.4 mg (0.8 mmol) of potassium carbonate into a dry 10 mL schlenk bottle. mmol), cyclohexane (2mL), and the reaction flask was stirred at 100°C for 24h. After the reaction was completed, the reaction solution was filtered through a glass dropper containing silica gel, rinsed with ethyl acetate, the filtrate was spin-dried, and separated by column chromatography to obtain the target product, a colorless oily liquid, with a yield of 77%.
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