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A method for extracting paclitaxel from yew

A technology of yew and paclitaxel, applied in the field of green process chemistry, can solve the problems of low extraction efficiency and the like

Active Publication Date: 2019-02-22
INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The application provides a method for extracting paclitaxel from yew to solve the problem of low extraction efficiency in the prior art

Method used

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  • A method for extracting paclitaxel from yew
  • A method for extracting paclitaxel from yew
  • A method for extracting paclitaxel from yew

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0050] see image 3 , Embodiment 2 of the present application shows a possible implementation of the method provided by the present application on the basis of the steps described in the preceding Embodiment 1, or in other words, shows the further detailed steps of the above-mentioned Embodiment 1, and The essential difference of the above-mentioned Example 1 is that in Example 2, eight different ionic liquids were selected to prepare extractants, and then the obtained extractants were used for ultrasonic extraction of yew powder, specifically:

[0051] Step S210, providing a raw material of yew, and preprocessing to obtain yew powder;

[0052] Step S220, providing 8 kinds of imidazole-type ionic liquids; including: 1-aminopropyl-3-methylimidazole chloride [APMIM]Cl, 1-hydroxyethyl-3-methylimidazole chloride [HOMIM]Cl, bromine 1-Butyl-3-methylimidazole [C 4 MIM]Br, 1-hydroxyethyl-3-methylimidazolium tetrachloride [HOMIM]FeCl 4 , 1-ethyl-3-methylimidazolium trichloroferric b...

Embodiment 3

[0068] see Figure 4 , Embodiment 3 of the present application shows another possible implementation of the method provided by the present application on the basis of the steps described in Embodiment 1 and Embodiment 2 above. The essential difference from Embodiment 2 above is that Embodiment 3 provides 5 kinds of extractants with different mass concentrations of ionic liquids, and then use the obtained extractants to ultrasonically extract the yew powder; specifically:

[0069] Step S310, providing a raw material of yew, and preprocessing to obtain yew powder;

[0070] Step S320, providing 5 kinds of extractants with different concentrations of ionic liquids; the organic solvents included in the 5 kinds of extractants are all methanol aqueous solutions with a volume concentration of 60%; the ionic liquids included in the 5 kinds of extractants are all 1- Butyl-3-methylimidazole trichloroferric monobromide liquid; the mass concentration of 1-butyl-3-methylimidazole trichloro...

Embodiment 4

[0080] see Figure 5 , Embodiment 4 of the present application shows another possible implementation of the method provided by the present application on the basis of the steps described in the foregoing Embodiments 1 to 3. The essential difference from the foregoing embodiments is that Embodiment 4 provides 5 A kind of extractant, these 5 kinds of extractants respectively comprise the aqueous methanol solution of different volume concentration, utilize the extractant obtained again to carry out ultrasonic extraction to yew powder; Specifically:

[0081] Step S410, providing a raw material of yew, and preprocessing to obtain yew powder;

[0082] Step S420, providing 5 kinds of aqueous methanol solutions with different concentrations; the volume concentrations of the 5 kinds of methanol aqueous solutions are: 50%, 60%, 70%, 80% and 90% respectively;

[0083] Step S430, providing 5 kinds of extractants corresponding to the 5 methanol aqueous solutions in step S420; all of the 5...

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Abstract

The invention discloses a method for extracting taxol from taxus chinensis. The method comprises the following step: extracting taxol from 80-mesh taxus chinensis powder by adopting an extracting agent containing an organic solvent and imidazole ionic liquid. By adopting the method for extracting taxol from taxus chinensis provided in the embodiment of the invention, the extraction rate in extraction of the taxol from the taxus chinensis powder is up to 0.2299mg / g when the volume concentration of a methanol aqueous solution in the extracting agent is 60 percent, the mass concentration of ionic liquid 1-butyl-3-methylimidazole trichlorine-iron bromide is 1.17 percent, the liquid-solid ratio is 10.5 to 1, the ultrasonic extraction temperature is 40 DEG C, and the ultrasonic extraction time is 30.17 minutes. By adopting the method provided by the invention, the taxol is extracted from the taxus chinensis, the extraction efficiency can be increased effectively, the dosage of methanol serving as an organic solvent in an extraction process is reduced, and the extraction time is shortened at the same time.

Description

technical field [0001] The application relates to the field of green process chemistry, in particular to a method for extracting paclitaxel from yew. Background technique [0002] Paclitaxel is a pentacyclic triterpenoid compound present in certain natural plants, with a structural formula such as figure 1 shown. Paclitaxel in its pure form is white crystalline powder, odorless and tasteless, insoluble in water but easily soluble in organic solvents such as chloroform and acetone. Paclitaxel has unique anticancer and antitumor effects. [0003] Paclitaxel is mainly extracted from Taxus plants. For example, paclitaxel is contained in the dry roots, branches, leaves and bark of Taxus chinensis, but the content is relatively low. Taking the bark of Taxus chinensis as an example, the content of paclitaxel is only 0.01% of the dry weight of the bark. Under natural conditions, yew grows slowly and has poor regeneration ability. It is recognized as a rare natural anti-cancer pl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D305/14
CPCC07D305/14
Inventor 谭志坚王朝云周晚来易永健汪洪鹰杨媛茹
Owner INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI