A kind of preparation method of pentafluorophenol
A technology of pentafluorophenol and toluene, applied in the field of preparation of pentafluorophenol, can solve the problems of high manufacturing cost, waste of bromine resources, environmental pollution and the like
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[0053] The first aspect of the present invention provides a kind of preparation method of pentafluorophenol, the structure of described pentafluorophenol is as shown in formula I:
[0054]
[0055] The preparation method of pentafluorophenol provided by the present invention can comprise decarboxylation reaction, and described decarboxylation reaction is specifically: the compound of formula II is under the condition that alkali exists, generates the compound of formula III, and reaction equation is as follows:
[0056]
[0057] In the decarboxylation reaction, the reaction can usually be carried out under the condition of gas protection, and the gas protection can use one or more combinations of nitrogen, inert gas, etc., and the inert gas can be, for example, helium, neon , argon, krypton, xenon, etc. one or more combinations.
[0058] In the decarboxylation reaction, the reaction can be carried out in the presence of a reaction solvent, which can be an organic solvent...
Embodiment 1
[0083] 1L three-necked flask, add 424 grams of pentafluorobenzoic acid, 1060 grams of toluene, and 202 grams of triethylamine. Heating to 100°C-110°C, reacting for 24 hours, the conversion is complete. Atmospheric pressure recovery triethylamine and toluene. Distilled to obtain 335g of pentafluorobenzene, GC area normalization method purity (A%): 99%, yield: 99%. GCMS: 168.
Embodiment 2-6
[0085] The consumption and kind of organic solvent are as shown in table 1, and other is with embodiment 1, and its result is shown in table 1
[0086] Table 1
[0087]
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