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Multi-organ chip based on microfluidics and preparation method of multi-organ chip

A microfluidic technology, multi-organ technology, applied in the methods of stress-stimulated microbial growth, biochemical equipment and methods, and the determination/inspection of microorganisms, which can solve the related work of the assembly and simulation of various tissues or organs. and other problems, to achieve the effect of easy control and observation.

Inactive Publication Date: 2017-06-09
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the application of microfluidic chip technology to simulate a single tissue or organ has been carried out, but the related work of assembling and simulating multiple tissues or organs on the same chip is still in a blank stage.

Method used

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  • Multi-organ chip based on microfluidics and preparation method of multi-organ chip
  • Multi-organ chip based on microfluidics and preparation method of multi-organ chip

Examples

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Embodiment 1

[0019] A multi-organ chip based on microfluidic technology, such as figure 1 Shown: a multi-organ chip chip based on microfluidic technology mainly includes a three-layer structure, an upper chip 1, a middle carbonate membrane 5 and a lower chip 6; the middle carbonate membrane 5 has micropores, and the upper chip 1 cultures The metabolites produced by the cells can permeate into the lower chip 6 through the micropores, thereby stimulating the cells or tissue models cultured in the lower chip 6 .

[0020] The upper layer chip 1 includes an upper layer cell inlet 2, an upper layer cell channel 3 and an upper layer cell outlet 4; the upper layer cell inlet 2 and the upper layer cell outlet 4 are connected through the upper layer cell channel 3;

[0021] The lower layer chip 6 includes a lower layer collagen inlet 7, a lower layer collagen channel 8, a lower layer cell inlet 9, a lower layer cell outlet 10 and a lower layer cell channel 11, the lower layer collagen inlet 7 is con...

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Abstract

The invention provides a multi-organ chip based on microfluidic technology and a preparation method thereof. The microfluidic chip is mainly composed of an upper chip, a carbonate film and a lower chip. The preparation method is as follows: the upper chip and the carbonate film are sealed with oxygen plasma; after the upper surface of the upper and lower chips is dipped in PDMS, it is aligned and bonded with the upper chip that has been irreversibly sealed with the carbonate film. The advantages of the present invention are: using the multi-layer microfluidic chip integration method, combining the culture units of various cells, and assembling and constructing the models of various organs on the same chip according to the sequence of operation between organs in the body , realizes the multi-organ combination chip construction method conveniently and quickly, and the organs can be effectively divided, which is convenient for the separate control and observation of each organ.

Description

technical field [0001] The invention relates to the application of microfluidic chip technology to the field of simulation and application of multiple tissues and organs in vitro, in particular to a multi-organ chip based on microfluidic technology and a preparation method thereof. Background technique [0002] In the process of medical research and new drug development, suitable models are an important aspect of conducting research. Animal experimental models have been produced. At the same time, in order to study the impact of new drugs on the human body, scientists began to cultivate human cells in petri dishes to see if these new drugs have toxic side effects on human cells. However, animal and human isolated cells cannot open the door for human beings to test drugs. According to statistics, only 10.8% of the drugs successfully passed the Phase III clinical trials. The main reason is that the curative effect is not good, and even have toxic side effects on the human bod...

Claims

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Application Information

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IPC IPC(8): C12M3/06C12Q1/02
CPCC12M23/16C12M35/08C12N2503/02G01N33/5058G01N33/5064G01N33/5067
Inventor 秦建华许慧李中玉
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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