Application of novel pterosin compound in treating diabetes mellitus

A technology for type 2 diabetes and compounds, which is applied in the application field of new fern compounds and preparation of drugs for the prevention and treatment of diabetes-related diseases, and can solve problems such as no new fern compounds.

Inactive Publication Date: 2017-06-13
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are no reports on the application of new fern compounds in diabetes-related diseases

Method used

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  • Application of novel pterosin compound in treating diabetes mellitus
  • Application of novel pterosin compound in treating diabetes mellitus
  • Application of novel pterosin compound in treating diabetes mellitus

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Embodiment Construction

[0016] Further description is given below by examples, but the present invention is not limited to the scope described in examples. For those skilled in the art, on the premise of not departing from the method of the present invention, some improvements and supplements can be made, and these improvements and supplements are also regarded as the protection scope of the present invention.

[0017] (1) Extraction and separation

[0018] (1) Extraction: take the original medicinal material of Pteridaceae plant, extract it with 80% ethanol aqueous solution under reflux, and concentrate the extract under reduced pressure to obtain the extract.

[0019] (2) Separation: add water to suspend, sequentially use petroleum ether, ethyl acetate, n-butanol for solvent distribution, and concentrate under reduced pressure to obtain the petroleum ether part, ethyl acetate part, n-butanol part, and water part. After the ethyl acetate part is absorbed by the macroporous resin, it is sequentially...

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PUM

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Abstract

The invention discloses the application of a novel pterosin compound in treating diabetes mellitus, relates to the field of natural medicines, particularly relates to the novel pterosin compound (shown in general formulas 1-3) extracted and separated from pteris plants, and discloses the application of the novel pterosin compound in preparing diabetes mellitus drugs. Experiments show that the novel pterosin compound has an obvious insulin antagonism resisting effect and has the advantages of low toxicity and high efficiency. The novel pterosin compound is suitable for pharmaceutically acceptable pharmaceutical excipients, can be prepared into commonly used preparations such as injections, tablets, capsules and so on and can be used for preventing and treating the diabetes mellitus.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to the application of novel fern compounds extracted and separated from Pteridaceae plants in the preparation of medicines for preventing and treating diabetes-related diseases. Background technique [0002] With the rapid development of human society and economy, the gradual improvement of living standards, the modernization of life patterns and the continuous extension of life expectancy, the incidence of diabetes has also increased significantly, and its complications have brought permanent disability and even death to patients. , Seriously affect the quality of life and life safety of patients. However, the drugs currently used to treat diabetes have many problems such as intermittent failure, obvious toxic and side effects, and high drug prices, which cannot well meet the needs of clinical treatment. Therefore, there is an urgent need for a new type of antidiabetic drug that is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/665C07D311/94C07D493/04A61K31/122A61K31/352A61P3/10
CPCC07C49/665C07D311/94C07D493/04
Inventor 舒积成刘建群彭财英袁金斌黄慧莲黄小英杨明
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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