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Antibacterial hemostatic gauze and preparation method thereof

A technology of hemostatic gauze and gauze, which is applied in the fields of medical formula, medical science, absorbent pads, etc. It can solve the problems of antibacterial agent enrichment, lack of antibacterial function, antibacterial drug resistance, etc., and achieve permeability change and excellent hemostatic function , Excellent antibacterial properties

Inactive Publication Date: 2017-06-13
GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing ordinary hemostatic gauze does not have antibacterial function, and the hemostatic effect is poor
Even if some new gauzes that appear at present have antibacterial function, they are generally added with antibacterial drugs or nano-silver and other antibacterial agents, so there are still problems of antimicrobial drug resistance and the enrichment of released nano-silver and other antibacterial agents

Method used

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  • Antibacterial hemostatic gauze and preparation method thereof
  • Antibacterial hemostatic gauze and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A preparation method of antibacterial hemostatic gauze, the specific steps of the preparation method are as follows:

[0022] S1. Preparation of quaternary ammonium salt monomer: use dichloromethane as solvent, add 200ml of dichloromethane into a single-mouth bottle, add 10g of methacrylic acid 2-(N,N-dimethylamine at a mass ratio of 2.5:1 Base) ethyl ester (DMAE) and 4g benzyl chloride, then add 0.5g hydroquinone as a polymerization inhibitor, heat and reflux for 5h, cool down after the reaction, a large number of white crystals precipitate, filter with suction, and weigh with dichloromethane Crystallize twice, dry in a vacuum oven at room temperature to obtain methacryloyloxyethyl-benzyl-dimethylammonium chloride monomer, which is a quaternary ammonium salt monomer;

[0023] S2, medical absorbent cotton gauze irradiation grafting: add 10g medical absorbent cotton gauze, the quaternary ammonium salt monomer and 100ml deionized water that step S1 obtains in the conical ...

Embodiment 2

[0025] A preparation method of antibacterial hemostatic gauze, the specific steps of the preparation method are as follows:

[0026] S1. Preparation of quaternary ammonium salt monomer: use dichloromethane as solvent, add 200ml of dichloromethane into a single-necked bottle, add 15g of methacrylic acid 2-(N,N-dimethylamine at a mass ratio of 1:1 Base) ethyl ester (DMAE) and 15g of benzyl chloride, then add 0.8g of hydroquinone as a polymerization inhibitor, heat and reflux for 7h, cool down after the reaction, a large number of white crystals precipitate, filter with suction, and weigh with dichloromethane Crystallize twice, dry in a vacuum oven at room temperature to obtain methacryloyloxyethyl-benzyl-dimethylammonium chloride monomer, which is a quaternary ammonium salt monomer;

[0027] S2, medical absorbent cotton gauze irradiation grafting: add 11g medical absorbent cotton gauze, the quaternary ammonium salt monomer and 100ml deionized water that step S1 obtains in the co...

Embodiment 3

[0029] A preparation method of antibacterial hemostatic gauze, the specific steps of the preparation method are as follows:

[0030] S1. Preparation of quaternary ammonium salt monomer: use dichloromethane as solvent, add 200ml of dichloromethane into a single-mouth bottle, add 20g of methacrylic acid 2-(N,N-dimethylamine at a mass ratio of 1:1.5 Base) ethyl ester (DMAE) and 30g of benzyl chloride, then add 1.0g of hydroquinone as a polymerization inhibitor, heat and reflux for 8h, cool down after the reaction, a large number of white crystals precipitate, filter with suction, and weigh with dichloromethane Crystallize twice, dry in a vacuum oven at room temperature to obtain methacryloyloxyethyl-benzyl-dimethylammonium chloride monomer, which is a quaternary ammonium salt monomer;

[0031] S2, medical absorbent cotton gauze irradiation grafting: add 12g medical absorbent cotton gauze, the quaternary ammonium salt monomer and 100ml deionized water that step S1 obtains in the c...

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Abstract

The invention relates to the technical field of medical appliance article preparation, and discloses antibacterial hemostatic gauze and a preparation method thereof. The antibacterial hemostatic gauze is obtained through preparing quaternary ammonium salt monomers and performing radiation grafting on medical absorbent cotton gauze. The antibacterial hemostatic gauze has the hemostatic function and has excellent hemostatic performance; the effects of fast stopping bleeding and diminishing inflammation can be achieved without adding any medicine. The antibacterial hemostatic gauze provided by the invention achieves the antibacterial goal by contact type antibacterial operation instead of antibacterial agent releasing.

Description

technical field [0001] The invention relates to the technical field of preparation of medical equipment, in particular to an antibacterial hemostatic gauze and a preparation method thereof. Background technique [0002] According to statistics, the main cause of death on the battlefield is excessive blood loss, accounting for about 50% of the total, while in peacetime, 39% of people who died due to trauma died from excessive blood loss. Hemorrhage that has not been effectively controlled is already The second leading cause of traumatic death. Even if the bleeding can be gradually controlled over a long period of time, excessive blood loss usually leads to serious consequences such as wound infection, hypothermia, coagulopathy or multiple organ failure. [0003] The existing common hemostatic gauze does not have antibacterial function, and the hemostatic effect is relatively poor. Even if some new gauzes that appear at present have antibacterial function, they are generally...

Claims

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Application Information

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IPC IPC(8): D06M14/22A61L15/24A61L15/46A61L15/62
CPCD06M14/22A61L15/24A61L15/46A61L15/62A61L2300/208A61L2300/404A61L2300/604A61L2400/04C08L51/02
Inventor 卢亢陈锦涛吴帅
Owner GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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