A linear model-based method for identifying key regulators in gene co-regulatory networks
A technology of regulating network and linear model, applied in the field of computational biology, can solve the problems of high time complexity, failure to consider interaction and cooperative regulation relationship, and the recognition accuracy needs to be improved, so as to achieve the effect of improving accuracy and achieving simplicity.
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[0049] 1. Identification model of key regulators in gene co-regulatory network based on linear model
[0050] In the present invention, the key regulators in the gene co-regulation network are defined as: using gene expression profile data and gene regulation relationship, by constructing a linear model to predict the expression of known disease genes, thereby identifying the genes that seriously affect the disease in the co-regulation network Regulators of expression.
[0051] In order to clearly describe the key regulator identification model in the gene co-regulatory network based on the linear model, the inventors define the model as follows:
[0052] The proposed construct linear model predicts the expression of known disease genes in the form of:
[0053]
[0054] The goal of the linear model-based key regulator identification model in the gene co-regulatory network is to identify the regulators that seriously affect the expression of disease genes in the co-regulato...
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