Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of pearl extract in preparation of medicine, health care product and cosmetic capable of inhibiting generation of presenilin

A technology of extracts and health products, applied in the application field of pearl extracts, can solve the problems of lack of effective data support and urgent development of pearl anti-aging research, and achieve the effect of inhibiting the synthesis of progerin by fibroblasts

Active Publication Date: 2017-06-27
OSMUN BIOLOGICAL
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the principle of pearl anti-aging has not been supported by effective data, and the research on pearl anti-aging needs to be developed urgently

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of pearl extract in preparation of medicine, health care product and cosmetic capable of inhibiting generation of presenilin
  • Application of pearl extract in preparation of medicine, health care product and cosmetic capable of inhibiting generation of presenilin
  • Application of pearl extract in preparation of medicine, health care product and cosmetic capable of inhibiting generation of presenilin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Pearl extract extraction process steps: select Osman nano-pearl powder as raw material, use weak acid solution as extraction solution, carry out vacuum dissolution under the condition of 30-50, stir at low speed 80-120rpm for 0.5-3 hours, and 8000-12000rpm at high speed 0-3 hours Centrifuge and filter at 8°C at low temperature, take the supernatant, and fill the supernatant into a dialysis bag. Desalination: Use a dialysis bag with a molecular weight of 3000-5000Da to desalt for 3-5 days at an environment of 2-10°C. 1 volume of sample corresponds to 10-20 volumes of distilled water, changing the water 1-2 times a day. After freeze-drying into powder, it is pearl extract.

Embodiment 2

[0036] Pearl extract extraction process steps:

[0037] 1) Grinding pearls into nano-scale pearl powder (10-100nm);

[0038] 2) Use 10 times the mass of deionized water to bathe the nano-pearl powder for ultra-high pressure homogenization at 300MPa and 60°C for 0.5h. Centrifuge at low temperature at 4°C to obtain ultra-high pressure pearl extract and precipitate. And the precipitate was washed 3 times with ethanol solution, and then proceeded to the next step;

[0039]3) Extract the pearl active ingredient from the precipitate obtained above with supercritical equipment, the extraction pressure is 25MPa, the CO2 flow rate is 25KG / h, and the extraction time is 60min, which is supercritical pearl extract;

[0040] 4) Ultra-high pressure pearl extract and supercritical pearl extract

[0041] Collected by vacuum freeze-drying to obtain ultra-high pressure pearl protein and supercritical pearl protein.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an application of a pearl extract. According to the application, multiple extracting modes are utilized for obtaining a pearl active ingredient, experimental results show that the pearl extract has obvious capability of inhibiting fibroblasts from synthesizing presenilin, and presenilin content is reduced by about 4% compared to control. Extraction of the pearl extract and discovery of inhibiting synthesis of the presenilin provide one effective and valid active addition agent for medicines, cosmetics and health food.

Description

technical field [0001] The invention relates to the application of a pearl extract. Background technique [0002] Anti-aging is the most important topic of beauty and skin care. During the research on the aging process at home and abroad, it was found that the obvious pathology related to aging skin includes Hakanson-Gilford Progeria Syndrome (HGPS). This rare disease is characterized by accelerated aging and premature death. Cells with this disorder often have lamin A as a fragmented protein. This fragmented nucleoprotein A is called progerin. In 2006, some researchers discovered that in the normal aging process, even without any pathological or genetic mutation, progerin will accumulate in skin cells. And studies have shown that there are similar acquired defects in the nuclei of the elderly population as in patients with Progeria Syndrome. What's more, inhibiting the lamin A scission site that causes Hakanson-Gilford Progeria Syndrome (HGPS) would reverse aging-induce...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/17A61K35/618A61P39/06A61K8/98A61K8/64A61Q19/08A23L33/17
CPCA23V2002/00A61K8/64A61K8/987A61K35/618A61K38/1767A61Q19/08A23V2200/318A23V2250/54A23V2300/46A23V2300/44
Inventor 杨安全王菁张丽华骆建芬谢敏
Owner OSMUN BIOLOGICAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com