A cell gene translation process modeling method

A technology of translation process and modeling method, applied in the fields of computer virtual reality technology and biological information technology, it can solve the problem that static models cannot reflect the protein translation process more realistically, and achieve the effect of reducing blindness and improving efficiency.

Active Publication Date: 2017-06-27
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

Therefore, static models cannot more realistically reflect the actual protein translation process

Method used

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  • A cell gene translation process modeling method
  • A cell gene translation process modeling method
  • A cell gene translation process modeling method

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Embodiment Construction

[0041] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0042]We now focus on a higher level: examining the characteristics of protein synthesis during single-cell development in terms of expressed gene time series. In terms of application, this model is closer to the development of real cells, and the simulated result is a dynamic result. Relatively speaking, the previous research is more one-sided and static. Of course, biological processes are very complex, and we can only simulate the behavioral process of cellular protein expression on the surface. More essential issues, such as the driving force of the time series of gene expression, we have not yet covered.

[0043] Based on the TASEP model, the present invention combines the time series of gene expression and the possibility of errors in the translation process. The purpose is to analyze the speed of protein translation during the life of cell growth and develo...

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Abstract

The invention relates to a cell gene translation process modeling method comprising the steps of: according to experimental data of species, determining whether each gene expresses at each discrete time point; inquiring about genes at each discrete time point, and if genes express, performing initialization; otherwise performing no initialization; obtaining the quantity of initializations in each kind of mRNAs by comparing the copy quantity of mRNAs corresponding to each gene at each time point and the number of mRNAs at the previous time point; calculating the total initialization speed of mRNA molecules; calculating the total extension speed of ribosome molecules on corresponding mRNAs; obtaining the probability of events according to the total initialization speed and the total extension speed; according to the weight of the probability of events, selecting an event randomly; updating the states of various kinds of molecules. The method employs the principle of a completely asymmetric simple exclusion process, takes into consideration the dynamic change of gene expression, enables a translation process to show a time series feature and be closer to the essence of cell development, and is suitable for research of the nature of dynamic development of cells.

Description

technical field [0001] The invention relates to a method for modeling the dynamic translation process of Saccharomyces cerevisiae gene, which belongs to biological information technology, calculation method and computer virtual reality technology. Background technique [0002] Many basic life phenomena such as cell metabolism, growth and differentiation are controlled by the expression of genes in cells, and the regulation of genes is realized through their corresponding gene products. Protein is one of the most important gene products and thus its synthesis is also one of the most fundamental and critical reactions in the cell. More and more experimental evidence shows that the normal translation of proteins plays a key and vital role in maintaining the normal function of cells. Normal cells cannot tolerate severe errors in gene translation. In a life cycle of a cell, gene expression is carried out in an orderly manner, and which genes need to be expressed at which stage ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/12G06F19/18G06F19/20
CPCG06F19/34G16B5/00G16B20/00
Inventor 李国辉张鼎林赵然
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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