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A modeling method for cellular gene translation process

A technology of translation process and modeling method, which is applied in the field of bioinformatics and computer virtual reality technology, can solve the problem that static models cannot reflect the protein translation process more realistically, and achieve the effect of reducing blindness and improving efficiency

Active Publication Date: 2020-02-14
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

Therefore, static models cannot more realistically reflect the actual protein translation process

Method used

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  • A modeling method for cellular gene translation process
  • A modeling method for cellular gene translation process
  • A modeling method for cellular gene translation process

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Embodiment Construction

[0041] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0042]We now focus on a higher level: examining the characteristics of protein synthesis during single-cell development in terms of expressed gene time series. In terms of application, this model is closer to the development of real cells, and the simulated result is a dynamic result. Relatively speaking, the previous research is more one-sided and static. Of course, biological processes are very complex, and we can only simulate the behavioral process of cellular protein expression on the surface. More essential issues, such as the driving force of the time series of gene expression, we have not yet covered.

[0043] Based on the TASEP model, the present invention combines the time series of gene expression and the possibility of errors in the translation process. The purpose is to analyze the speed of protein translation during the life of cell growth and develo...

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Abstract

The present invention relates to a method for modeling the process of gene translation in cells, comprising the following steps: obtaining whether each gene is expressed at each discrete time point according to the experimental data of the species; querying the genes at each discrete time point, if the gene is expressed, Then initialize; otherwise, do not initialize; compare the number of mRNA copies corresponding to each gene at each time point with the number of mRNAs at the previous time point to obtain the number of initializations in various mRNAs; calculate the total initialization speed of mRNA molecules; calculate ribosomal molecules The total elongation speed on the corresponding mRNA; the probability of events is obtained according to the total initialization speed and the total elongation speed; an event is randomly selected according to the weight of the event probability; and the states of various molecules are updated. The invention adopts the principle based on a completely asymmetric and simple repulsion process, and considers the dynamic changes of gene expression at the same time, so that the translation process presents a time series feature, which is closer to the essence of cell development, and is suitable for studying the dynamic development properties of cells.

Description

technical field [0001] The invention relates to a method for modeling the dynamic translation process of Saccharomyces cerevisiae gene, which belongs to biological information technology, calculation method and computer virtual reality technology. Background technique [0002] Many basic life phenomena such as cell metabolism, growth and differentiation are controlled by the expression of genes in cells, and the regulation of genes is realized through their corresponding gene products. Protein is one of the most important gene products and thus its synthesis is also one of the most fundamental and critical reactions in the cell. More and more experimental evidence shows that the normal translation of proteins plays a key and vital role in maintaining the normal function of cells. Normal cells cannot tolerate severe errors in gene translation. In a life cycle of a cell, gene expression is carried out in an orderly manner, and which genes need to be expressed at which stage ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B25/00G16B40/00
CPCG16B5/00G16B20/00
Inventor 李国辉张鼎林赵然
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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