vascular flow tie

Abstract

The invention provides a blood vessel flow rate constraint wire and a use method of the blood vessel flow rate constraint wire, and belongs to the technical field of medicine. The blood vessel flow rate constraint wire and the use method of the blood vessel flow rate constraint wire solve the problems that in the existing animal experiment process, the operation on micro fine blood vessels is inconvenient and the precision is low. The blood vessel flow rate constraint wire is of an integral structure, and comprises a constraint main wire section and two wire typing sections; one end of each of the two wire tying sections is connected with one end of the constraint main wire section, or one ends of the two wire tying sections are in one-to-one correspondence tying connection with two ends of the constraint main wire section; projected nodes are arranged at a connecting position of the wire tying sections and one end of the constraint main wire section; the other end part of the constraint main wire section is at least provided with a constraint hole. The blood vessel flow rate constraint wire and an operation method for performing aorta coarctation by using the blood vessel flow rate constraint wire have advantages that the operation is convenient; the experiment errors are small; the experiment result is precise; the experiment animal death rate is low; the work intensity of operators is low; the operation effect is high.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a blood vessel flow control, in particular to a blood vessel flow binding wire. Background technique [0002] Animal experimentation refers to scientific research using animals in a laboratory to obtain new knowledge about biology, medicine, etc. or to solve specific problems. In the study of human cardiac hypertrophy, the exact mechanism has not been fully elucidated, so animal experiments can provide a theoretical basis for it. [0003] There are several methods for establishing myocardial hypertrophy models for experimental animals (rats and mice) including pressure overload method, volume load method, myocardial infarction method and hormone induction method. Among them, the aortic coarctation method, which belongs to the pressure overload method, has been widely used because of its low animal mortality rate, high model success rate, good reproducibility, and short formation ...

AI Technical Summary

Problems solved by technology

[0004] There are the following problems in the actual operation of the aortic coarctation method: 1. There are few optional needles in the range of φ0.3-0.5mm, so it cannot meet all operation requirements

2. The diameter of the aorta of a mouse (take a 25 g male C57 / B6J mouse as an example) is usually 0.8-1.0 mm. When cutting the needle, it is usually broken with a vascular forceps. The force can cause it to deform and change its diameter, and slight operational errors will affect the experimental results in mice

3. After the needle is broken, the broken end is usually not smooth, and it is easy to have burrs. When the needle is withdrawn, it is easy to damage local tissues and blood vessels.

4. The mousse thread used for knotting is a multi-strand thread, and its length will change slightly under different stress conditions, which will affect the experimental results; there are many residual gaps in the multi-strand thread, which increases the chance of infection of experimental animals

5. If the mousse thread is too thin, it will increase the cutting effect on the artery and damage the blood vessel; if the mousse thread is too thick, it will affect the control accuracy of the blood vessel, and then affect the experimental results; if the thread knot is too large, it will also affect the blood vessel

6. When binding the needles, because the needles are not assisted in fixing, the needles often slip or fall off, and repeated operations are required, which is time-consuming and labor-intensive

Images