Circulating tumor cell capturing device

A tumor cell and capture device technology, which is applied in the field of medical devices, can solve the problems of inability to play a therapeutic role, prone to errors, and inability to detect tumor cells, so as to reduce the probability of tumor metastasis, reduce damage, and inhibit the spread.

Pending Publication Date: 2017-07-18
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the small volume of in vitro detection, the tumor cells in the whole body cannot be detected, errors are prone to occur, multiple measurements are required, and it cannot play a therapeutic role.

Method used

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  • Circulating tumor cell capturing device
  • Circulating tumor cell capturing device
  • Circulating tumor cell capturing device

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Embodiment Construction

[0025] The present invention will be further described below in conjunction with specific examples.

[0026] Such as Figure 2 to Figure 5 As shown, a circulating tumor cell capture device includes one or more containers for processing and collecting circulating tumor cells, and the inner wall of the container is embedded with antibodies that can specifically bind to circulating tumor cells, or the surface is modified with Nanoparticles of the antibody. The antibodies are anti-epithelial cell adhesion protein (EpCAM), cytokeratin (cytokeratin, CK), vascular endothelial growth factor (vascular endothelial growth factor, VEGF), epidermal growth factor receptor 1 (epidermal growth factor receptor, EGFR) 1. One or more of the proto-oncogene human epidermal growth factor receptor-2 (human epidermal growth factor receptor-2, HER2) antibody.

[0027] The nanoparticles are one or more of magnetic nanoparticles, gold nanoparticles, silicon dioxide nanoparticles, metal-organic framewo...

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Abstract

The invention discloses a circulating tumor cell capturing device. The circulating tumor cell capturing device comprises one or more containers for treating and collecting circulating tumor cells, wherein antibodies capable of being specifically bonded with the circulating tumor cells, or nanoparticles of which the surfaces are modified with the antibodies are embedded into the inner wall of each container; the container is a spiral container, or a straight cylindrical container with a threaded structure, so that liquid flowing into the container can move forward spirally so as to generate a centrifugal force; compared with red blood cells and platelets, the circulating tumor cells can generate a larger centrifugal force, so that the circulating tumor cells are specifically bonded with the antibodies on the wall of the container. With combination of two principles, the circulating tumor cell capturing device can capture systemic CTCs (circulating tumor cells), so that the probability of tumor metastasis is reduced; moreover, the CTCs enriched on the inner wall of the container can be collected so as to further characterize and research the CTCs.

Description

technical field [0001] The invention relates to a circulating tumor cell capture device, which belongs to the technical field of medical devices. Background technique [0002] Tumor is a disease that is difficult to overcome in the current diseases, and after the tumor metastasizes, the survival rate of patients is greatly reduced. The process of tumor metastasis is very complicated, and it has certain reference value for the detection of circulating tumor cells (CTC), miRNA and exosomes in blood. As the pioneer of metastasis, CTC plays a vital role in tumor metastasis. [0003] At present, based on the principle of cell size and surface antibodies, the number of CTCs in a small amount of blood can be detected in vitro, which has a certain reference value for the treatment and prognosis of patients. However, due to the small volume of in vitro detection, it is impossible to detect tumor cells in the whole body, errors are prone to occur, multiple measurements are required,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36
CPCA61M1/362
Inventor 姜虎林何玉静邢磊
Owner CHINA PHARM UNIV
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