Preparation method of ethyl nicotinate

Abstract

The invention relates to a preparation method of ethyl nicotinate. The preparation method is characterized by comprising the following steps of: adding nicotinic acid, absolute ethyl alcohol and an esterification reaction solid acid catalyst into methylbenzene; stirring the mixture to react for 3-6h at 50-65 DEG C; then raising the temperature to return and divide water; finishing the reaction till no water is divided; reducing the temperature to room temperature; filtering and recovering the esterification reaction solid acid catalyst; recovering methylbenzene at a reduced pressure from the filtrate; recovering the methylbenzene to obtain a light yellow transparent liquid which is the finished product ethyl nicotinate, wherein the molar ratio of nicotinic acid and absolute ethyl alcohol is 1: 1 to 1: 2; the weight ratio of nicotinic acid and methylbenzene is 1:0.3 to 1:8; the adding amount of the esterification reaction solid acid catalyst is 0.01-0.1 time of the weight of the nicotinic acid; the esterification reaction solid acid catalyst is an HND230 solid catalyst. The preparation method provided by the invention has the advantages of reducing generation of highly polluted wastewater, reducing the manual and equipment costs and being relatively suitable for industrial production on a large scale.

Description

technical field [0001] The invention relates to a method for preparing ethyl nicotinate, in particular to a method for preparing ethyl nicotinate through a reaction catalyzed by a solid acid catalyst. Background technique [0002] As an important basic chemical raw material, ethyl nicotinate is widely used in the synthesis of medicine and pesticide. At present, the more economical and mainstream synthesis method is to use concentrated sulfuric acid as a catalyst, and carry out esterification reaction between nicotinic acid and absolute ethanol under reflux. PH, then extracted with ethyl acetate, dried over anhydrous sodium sulfate, and distilled off ethyl acetate under reduced pressure. The residue is a light yellow transparent liquid which is the product. The advantage of this process is that the process is relatively simple and the yield is high. The disadvantage is that the loss of anhydrous ethanol and ethyl acetate is large and the cost is high; at the same time, the ...

AI Technical Summary

Problems solved by technology

The advantage of this process is that the process is relatively simple and the yield is high. The disadvantage is that the loss of anhydrous ethanol and ethyl acetate is large and the cost is high; at the same time, the process will produce a large amount of high-COD and high-sodium sulfate wastewater, which also greatly improves wastewater treatment. The cost is not conducive to large-scale industrial production. The reaction formula is as follows