Polymeric micelle capable of realizing synchronous administration of sorafenib and curcumin and preparation method of polymeric micelle

A kind of polymer glue and polymer technology, which is applied in the direction of medical preparations, drug combinations, and pharmaceutical formulas of non-active ingredients, can solve the problems of no medicine available, and can not further expand the application range, etc., to achieve strong therapeutic effect and prolong Retention time, the effect of reducing toxic and side effects

Active Publication Date: 2017-08-18
LIAONING UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

In addition, drug resistance to sorafenib will also appear, because of the targeted efficacy of sorafenib, once drug resistance occurs, there will be no drug avai

Method used

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  • Polymeric micelle capable of realizing synchronous administration of sorafenib and curcumin and preparation method of polymeric micelle
  • Polymeric micelle capable of realizing synchronous administration of sorafenib and curcumin and preparation method of polymeric micelle
  • Polymeric micelle capable of realizing synchronous administration of sorafenib and curcumin and preparation method of polymeric micelle

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] 1. In vitro cell inhibitory activity of Sorafenib and curcumin raw materials in combination

[0030] (1) Solution configuration: Precisely weigh 60 mg of curcumin, 30 mg of sorafenib, 60 mg of curcumin plus 30 mg of sorafenib, and add 1 mL of dimethyl sulfoxide (DMSO) to three 10 mL plastic centrifuge tubes. , ultrasonically assisted dissolution, dissolved and moved into the ultra-clean bench, sucked 5 μL into 5mL culture medium respectively, filtered it with a 0.22 μm microporous membrane, used it as the original solution, and diluted it with the culture medium to 2 times as the different concentrations of drug-containing culture for MTT experiments base.

[0031] The final drug-containing medium concentration was:

[0032] a. Curcumin group: 60, 30, 15, 7.5, 3.75 μg / mL;

[0033] b. Sorafenib group: 30, 15, 7.5, 3.25, 1.875 μg / mL;

[0034] c. Combined medication group: curcumin concentration (μg / mL) / sorafenib concentration (μg / mL), 60 / 30, 30 / 15, 15 / 7.5,

[0035] 7....

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Abstract

The patent of the invention relates to a polymeric micelle capable of realizing synchronous administration of sorafenib and curcumin and a preparation method of the polymeric micelle, and belongs to the field of novel medicine preparations in health and medicines. The PCL-PEG-PCL (polycaprolactone -polyethylene glycol-polycaprolactone) is taken as a carrier material, the polymeric micelle capable of synchronously releasing sorafenib and curcumin is prepared according to a filming rehydration method, the solubility and the bioavailability of sorafenib and curcumin are improved, and the purposes of synergetic administration of medicines and enhancement of treatment effects are fulfilled. The patent concretely investigates the optimal polymer carrier material, the carrier material, the medicine dosage ratio, the rehydration temperature, time and volume of the filming rehydration method, the in vitro dissolution and the studies on in vivo pharmacokinetics of mice, the finally prepared polymeric micelle can realize synchronous administration of sorafenib and curcumin, the long-circulation effect is obvious, and the polymeric micelle has broad research significances and commercial popularization prospect.

Description

technical field [0001] The invention relates to a polymer micelle capable of simultaneously administering sorafenib and curcumin and a preparation method thereof, belonging to the field of medicine and health. Background technique [0002] Cancer affects everyone—whether young or old, rich or poor, man, woman or child. It is a huge burden for patients, families and society. Cancer is one of the leading causes of death in the world, especially in developing countries. According to data published on the WHO website, a total of 8,800,000 people died of cancer worldwide in 2015, including 1,690,000 lung cancers, 788,000 liver cancers, and colorectal cancers. There are 774,000 people with cancer, 754,000 people with gastric cancer, and 571,000 people with breast cancer. One out of every six deaths is due to cancer. In the next 20 years, the number of new cancer patients will continue to increase by 70%. Cancer has become more and more influential. to people's lifespan (CHEN W, Z...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/34A61K31/44A61K31/12A61P35/00
CPCA61K9/1075A61K31/12A61K31/44A61K47/34A61K2300/00
Inventor 陈立江崔庆国刘宇
Owner LIAONING UNIVERSITY
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