Method for cancer treatment based on combination of drugs

A cancer treatment and drug delivery technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as the inability to administer drugs by systemic injection, and increase the range of selectivity and range Increased, good therapeutic effect

Pending Publication Date: 2020-10-30
王成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In the first aspect, after various attempts, a new freeze-dried powder injection of ingenol methacrylate was developed, which solved the problem of hydrophobicity of ingenol methacrylate, improved its stability, and achieved a breakthrough It solved the clinical "bottleneck" of its inability to administer systemic injections

Method used

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  • Method for cancer treatment based on combination of drugs
  • Method for cancer treatment based on combination of drugs
  • Method for cancer treatment based on combination of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) MPEG-PDLLA and I3A are co-dissolved in 100mL of absolute ethanol according to a certain mass ratio (9g:1g), ultrasonically dissolved and added to a spray dryer, and dried quickly, the dried powder is collected, and 850ml of 14% (W / V) Aqueous solution of sucrose for injection, after shaking and ultrasonically dissolving, adjust the pH value to 5.0 with citric acid, add 14% (W / V) aqueous solution of sucrose for injection to 1000ml scale, pressurize and filter at 0.22um, divide the filtrate, 1ml / bottle, placed in a lyophilizer to quickly freeze to -40°C, pre-frozen for 4 hours, and then sublimated and dried to obtain I3A-PM lyophilized powder for future use. When in use, take 1 bottle of I3A-PM freeze-dried powder and add 2ml of water for injection or 0.9% sodium chloride water for injection or glucose water for injection, shake to dissolve, after the bubbles dissipate, draw out and add 500ml of normal saline or glucose water for injection, intravenously Infusion.

Embodiment 2

[0043] (2) MPEG-PCL and I3A are co-dissolved in 100mL of absolute ethanol according to a certain mass ratio (9g:1g), ultrasonically dissolved and added to a spray dryer, dried quickly, and the dried powder is collected, and 850ml of 14% (W / V) Aqueous solution of sucrose for injection, after shaking and ultrasonically dissolving, adjust the pH value to 5.0 with citric acid, add 14% (W / V) aqueous solution of sucrose for injection to 1000ml scale, pressurize and filter at 0.22um, divide the filtrate, 1ml / bottle, placed in a lyophilizer to quickly freeze to -40°C, pre-frozen for 4 hours, and then sublimated and dried to obtain I3A-PM lyophilized powder for future use. When in use, take 1 bottle of I3A-PM freeze-dried powder and add 2ml of water for injection or 0.9% sodium chloride water for injection or glucose water for injection, shake to dissolve, after the bubbles dissipate, draw out and add 500ml of normal saline or glucose water for injection, intravenously Infusion.

Embodiment 3

[0045] (3) PDLLA-PEG-PDLLA and I3A were co-dissolved in 100mL of absolute ethanol according to a certain mass ratio (9g:1g), ultrasonically dissolved and added to a spray dryer, dried quickly, and the dried powder was collected, and 850ml of 14% ( W / V) sucrose aqueous solution for injection, after shaking and ultrasonically dissolving, adjust the pH value to 5.0 with citric acid, add 14% (W / V) sucrose aqueous solution for injection to 1000ml scale, filter under 0.22um pressure, and pack the filtrate separately, 1ml / bottle, placed in a lyophilizer and quickly frozen to -40°C, pre-frozen for 4 hours, sublimated and dried to obtain I3A-PM lyophilized powder for later use. When in use, take 1 bottle of I3A-PM freeze-dried powder and add 2ml of water for injection or 0.9% sodium chloride water for injection or glucose water for injection, shake to dissolve, after the bubbles dissipate, draw out and add 500ml of normal saline or glucose water for injection, intravenously Infusion. ...

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Abstract

The invention relates to a preparation method and application of a cancer treatment composition containing an ingenol methyl butenoic acid ester compound polymer micelle and one or more antitumor agents such as taxane or platinum or camptothecin or an immune checkpoint inhibitor. According to the invention, a hydrophobic ingenol methyl butenoic acid ester compound is made into the nanoscale polymer micelle, and the nanoscale polymer micelle and one or more anti-tumor agents such as taxane or platinum or camptothecin or immune checkpoint inhibitors are used in a cancer treatment method. Resultsof researches show that the ingenol methyl butenoic acid ester has an immune activation effect and can be combined with chemotherapeutic drugs such as docetaxel to effectively improve anti-tumor effect, prolong lifetime and greatly reduce the toxic and side effects of chemotherapeutic drugs.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to polymer micelles containing ingenol methacrylate compounds as active ingredients, which are used for anti-aging agents such as taxanes or platinums or camptothecins or immune checkpoint inhibitors. A composition for cancer treatment in which one or more anti-tumor agents of the tumor agent are administered in combination. Background technique [0002] Chemotherapy is one of the "troika" of tumor treatment, but a single chemotherapy requires a large dose to kill tumor cells, which brings many adverse reactions to patients, such as severe systemic toxicity and immunosuppression. In order to reduce adverse reactions, enhance drug efficacy, and expand anti-cancer spectrum, chemotherapy drugs are commonly used in combination with other anti-tumor means. The process of tumorigenesis involves a series of complex interactions between tumor cells and other host cells, in which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K9/107A61K9/19A61K47/34A61K31/337A61K31/555A61K33/243A61K31/4745A61K31/22A61P35/00
CPCA61K9/0019A61K9/1075A61K9/19A61K31/22A61K31/337A61K31/4745A61K31/555A61K33/24A61K45/06A61K47/34A61P35/00A61K2300/00
Inventor 王成
Owner 王成
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