Application of IGKC, C9, AHSG and KNG1 in distinguishing tuberculous pleural effusion and malignant pleural effusion

A technology for malignant pleural effusion and pleural effusion, applied in the biological field, can solve the problems of false positive, false negative, difficult to popularize, etc.

Inactive Publication Date: 2017-08-18
BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV +1
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  • Abstract
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  • Claims
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Problems solved by technology

In recent years, some advanced molecular biology techniques have been applied to the detection of pleural effusion. For example, nucleic acid amplification detection technology has developed rapidly in the field of tuberculosis, but t

Method used

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  • Application of IGKC, C9, AHSG and KNG1 in distinguishing tuberculous pleural effusion and malignant pleural effusion
  • Application of IGKC, C9, AHSG and KNG1 in distinguishing tuberculous pleural effusion and malignant pleural effusion
  • Application of IGKC, C9, AHSG and KNG1 in distinguishing tuberculous pleural effusion and malignant pleural effusion

Examples

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Embodiment 1

[0066] Example 1. Differential proteins in patients with tuberculous pleural effusion and malignant pleural effusion

[0067] 1. Discovery of differential proteins between patients with tuberculous pleural effusion and malignant pleural effusion

[0068] 1. Samples and instruments

[0069] 5 cases were selected from TPE (tuberculous pleural effusion) patients, and the other 5 cases were MPE (malignant pleural effusion) patients, all of which were confirmed by laboratory and clinical diagnosis reports.

[0070] Patients with tuberculous pleural effusion, inclusion criteria: age ≥ 18 years old, HIV negative. Those who have the following items 1 to 3 combined with any of items 4 to 6 can be included: ① Clinical symptoms such as low fever, night sweats, weight loss, chest pain, dry cough, etc.; ② Pleural effusion consistent with exudate changes, pleural effusion cells The main components are lymphocytes and monocytes, and the adenosine deaminase (ADA) in pleural effusion is grea...

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Abstract

The invention discloses an application of IGKC, C9, AHSG and KNG1 in distinguishing tuberculous pleural effusion and malignant pleural effusion. A system for detecting the IGKC, C9, AHSG and KNG1 contents includes a system for detecting the IGKC content, a system for detecting the C9 content, a system for detecting the AHSG content and a system for detecting the KNG1 content by an enzyme-linked immunosorbent assay or a liquid chromatography-electrospray ionization tandem mass spectrometry. By using the system for detecting the IGKC, C9, AHSG and KNG1 contents, the accuracy in distinguishing patients with the tuberculous pleural effusion and patients with the malignant pleural effusion is 97.5%; the sensitivity in screening patients with the malignant pleural effusion is 100%, and the specificity is 96%; the sensitivity in screening patients with the tuberculous pleural effusion is 96%, and the specificity is 100%.

Description

technical field [0001] The invention relates to the application of IGKC, C9, AHSG and KNG1 in distinguishing tuberculous pleural effusion from malignant pleural effusion in the field of biotechnology. Background technique [0002] There is about 5-15ml of fluid in the pleural cavity of a normal person to separate the two layers of pleura, which acts as a lubricant during breathing. The amount of pleural fluid is not constant. Normal people also have 500-1000ml of fluid exudation and reabsorption every 24 hours, and the two are in a state of balance. Any reason causes increased exudation and (or) decreased reabsorption, and pleural effusion occurs when fluid in the pleural cavity increases. Pleural effusions are commonly tuberculous pleural effusions and malignant pleural effusions. Tuberculous pleurisy is caused by tuberculous pleurisy, which is caused by Mycobacterium tuberculosis. Tuberculous pleurisy is a common clinical extrapulmonary tuberculosis with a high incidence...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N30/02
CPCG01N30/02G01N33/6848
Inventor 潘丽萍张宗德李琦张霞贾红彦孙会姗
Owner BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
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