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Three-dimensional focused-flow micro-fluidic chip used for synthesis of liquid drops and preparation method thereof

A microfluidic chip and manufacturing method technology, applied in chemical instruments and methods, laboratory utensils, laboratory containers, etc., can solve the problems of difficult droplets and difficult to form focused flow, etc.

Inactive Publication Date: 2017-09-05
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the capillary-in-tube chip is not easy to form a focused flow, and it is difficult to generate droplets of several microns. At the same time, the glass material is hydrophilic, and the water-in-oil experiment needs to be modified in advance on the surface of the capillary.

Method used

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  • Three-dimensional focused-flow micro-fluidic chip used for synthesis of liquid drops and preparation method thereof
  • Three-dimensional focused-flow micro-fluidic chip used for synthesis of liquid drops and preparation method thereof
  • Three-dimensional focused-flow micro-fluidic chip used for synthesis of liquid drops and preparation method thereof

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Embodiment Construction

[0035] The embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary, and is not intended to limit the scope of the present invention and its application.

[0036] In one embodiment, a three-dimensional focused flow synthesis droplet microfluidic chip includes a continuous phase layer and a discrete phase layer. The continuous phase layer includes a continuous phase flow channel 502, a continuous phase reservoir 503, and an anti-clogging An array structure 507, a fluid output channel 505 and a fluid output port 506. The discrete phase layer includes a discrete phase channel 501, a discrete phase reservoir 504, and a constriction structure 508; the continuous phase channel 502 is from the continuous phase reservoir Beginning at 503, the anti-clogging array structure 507 filters out the residues in the fluid to form a flow channel, which is divided into two continuous phase flow channels 502 in t...

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Abstract

The invention provides a three-dimensional focused-flow micro-fluidic chip used for synthesis of liquid drops and a preparation method thereof. The chip comprises a continuous-phase layer and a dispersed-phase layer; the continuous-phase layer comprises a continuous-phase channel, a continuous-phase fluid storage tank, an anti-blockage array structure, a fluid output channel and a fluid outlet; the dispersed-phase layer comprises a dispersed-phase channel, a dispersed-phase fluid storage tank and a contraction port; the continuous-phase channel begins at the continuous-phase fluid storage tank, passes through the anti-blockage array structure and is then divided into two branch continuous-phase channels which are symmetrically located at two sides of the dispersed-phase channel and intersect and communicate with each other at the outlet of the dispersed-phase channel, and then the continuous-phase channel enters the fluid output channel via the contraction port; the width of the contraction port is less than the width of the dispersed-phase channel; and the depth of the continuous-phase channel is greater than the depths of the dispersed-phase channel and the contraction port, and the outlet of the continuous-phase channel is located at the center of the continuous-phase channel in transverse and depth directions. The micro-fluidic chip can easily generate focused flow and stably produce submicron liquid drops.

Description

Technical field [0001] The invention relates to a three-dimensional focused flow synthesis droplet microfluidic chip and a manufacturing method thereof. The microfluidic chip can be used in conjunction with a mass spectrometer to generate tiny droplets in a gas-liquid two-phase flow. Background technique [0002] Microfluidic chips, especially integrated microfluidic chips with high-density, large-scale, high-throughput, and multi-functional characteristics, have played an important role in the fields of chemistry and biology. Compared with macro-scale experimental devices, this technology significantly reduces sample consumption and improves reaction efficiency. At the same time, it also reduces the environmental pollution of the waste generated by the experiment; the parallel advantages of the integrated microfluidic chip operation can achieve high-throughput and automated control of the experiment; and can be accurately controlled by micro-valves, micro-pumps and other fine st...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/5027B01L2300/0874
Inventor 钱翔吴艳王晓浩张旻董瑛
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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