Preparation auxiliary agent of volatile oil obtained by extracting traditional Chinese medicine

A volatile oil and the obtained technology are applied in the directions of non-active medical preparations, pharmaceutical formulations, oil/fat/wax non-active ingredients, etc., and can solve the problems of rarely checking the content of volatile oil, rarely examining the stability of volatile oil, etc. Improve stability and ensure the effect of curative effect

Inactive Publication Date: 2017-09-15
ANHUI RENZHITANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of volatile oil is rarely checked in the quality standards of finished traditional Chinese medicine preparations, and the stability of volatile oil is rarely investigated in stability test research.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of preparation aids: Add 0.5g sorbitol and 0.5g hydrogenated palm oil to 3g microcrystalline cellulose, raise the temperature to 55-60°C and grind for 10min, and transfer to 0-5°C environment to seal and stand for 1h, then Heat up to 70-75°C and keep grinding for 10 minutes, then add 10g of poloxamer / polyglutamic acid and 2g of pregelatinized hydroxypropyl starch / citric acid, continue to keep warm and grind for 10 minutes, and the resulting mixture is naturally cooled to room temperature, and finally used The ultrafine pulverizer makes fine powder.

[0019] Preparation of poloxamer / polyglutamic acid: Mix 10g of poloxamer 188 and 10g of food-grade polyglutamic acid, raise the temperature to 130-135°C and grind for 30min, and add an equal weight of Boil water, reflux and keep stirring for 10 minutes, then add 1g hydrogenated castor oil and 0.5g polydiallyl dimethyl ammonium chloride, continue to reflux and keep stirring for 30 minutes, and the resulting mixtur...

Embodiment 2

[0023] Preparation of preparation aids: Add 1g of sorbitol and 0.5g of hydrogenated palm oil to 5g of microcrystalline cellulose, raise the temperature to 55-60°C and grind for 15 minutes, then transfer to an environment of 0-5°C to seal and stand for 1h, then raise the temperature Heat and grind at 70-75°C for 5 minutes, then add 15g of poloxamer / polyglutamic acid and 3g of pregelatinized hydroxypropyl starch / citric acid, continue to heat and grind for 15 minutes, and cool the resulting mixture to room temperature naturally. The micro pulverizer makes fine powder.

[0024] Preparation of poloxamer / polyglutamic acid: Mix 5 g of poloxamer 188 and 5 g of food-grade polyglutamic acid, raise the temperature to 130-135 °C and grind for 30 minutes, and add an equal weight of Boil water, reflux and keep stirring for 10min, then add 0.5g hydrogenated castor oil and 0.5g polydiallyl dimethyl ammonium chloride, continue to reflux and keep stirring for 30min, and the resulting mixed solu...

Embodiment 3

[0040] The methods described in Example 1, Example 2, Comparative Example 1, Comparative Example 2, and Comparative Example 3 were used to entrap volatile oil respectively, and the immediate inclusion rate and preparation stability after inclusion of volatile oil were measured. The results are shown in Table 1.

[0041] Table 1 volatile oil inclusion rate and preparation stability

[0042] Measurement items

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PUM

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Abstract

The invention discloses a preparation auxiliary agent of volatile oil obtained by extracting traditional Chinese medicine, which relates to the technical field of a traditional Chinese medicine extract product preparation. The preparation auxiliary agent comprises the following raw materials in parts by weight: 10-15 parts of poloxamer/polyglutamic acid, 3-5 parts of microcrystalline cellulose, 1-3 parts of pregelatinized hydroxypropyl starch/citric acid, 0.5-1 part of sorbitol, and 0.5-1 part of hydrogenated palm oil. The prepared preparation auxiliary agent is used for inclusion of the volatile oil obtained by extracting traditional Chinese medicine, the instant inclusion rate after inclusion can reach 90% and above, the inclusion rate of the preparation after 6 months can reach 85% and above, and the inclusion rate of the preparation after 12 months can reach 80% and the above.

Description

Technical field: [0001] The invention relates to the technical field of traditional Chinese medicine extract preparations, in particular to a preparation auxiliary agent for volatile oil obtained from traditional Chinese medicine extraction. Background technique: [0002] Volatile oil is a general term for a class of volatile oily components present in plants that have an aromatic odor, can be distilled out with water vapor, and are immiscible with water. Most of the Chinese herbal medicines containing volatile oils or the extracted volatile oils have the effects of sweating, regulating qi, relieving pain, inhibiting bacteria, and correcting taste. When the pharmacological effects of volatile oils are consistent with the efficacy of preparations, volatile oils must be extracted and retained in the preparation process of traditional Chinese medicine. [0003] At present, the preparation process of many traditional Chinese medicine solid preparations is to directly spray the v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/10A61K47/34A61K47/38A61K47/36A61K47/12A61K47/26A61K47/44
CPCA61K47/10A61K47/12A61K47/26A61K47/34A61K47/36A61K47/38A61K47/44
Inventor 张振岭
Owner ANHUI RENZHITANG PHARMA CO LTD
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