Preparation auxiliary agent of volatile oil obtained by extracting traditional Chinese medicine
A volatile oil and the obtained technology are applied in the directions of non-active medical preparations, pharmaceutical formulations, oil/fat/wax non-active ingredients, etc., and can solve the problems of rarely checking the content of volatile oil, rarely examining the stability of volatile oil, etc. Improve stability and ensure the effect of curative effect
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Embodiment 1
[0018] Preparation of preparation aids: Add 0.5g sorbitol and 0.5g hydrogenated palm oil to 3g microcrystalline cellulose, raise the temperature to 55-60°C and grind for 10min, and transfer to 0-5°C environment to seal and stand for 1h, then Heat up to 70-75°C and keep grinding for 10 minutes, then add 10g of poloxamer / polyglutamic acid and 2g of pregelatinized hydroxypropyl starch / citric acid, continue to keep warm and grind for 10 minutes, and the resulting mixture is naturally cooled to room temperature, and finally used The ultrafine pulverizer makes fine powder.
[0019] Preparation of poloxamer / polyglutamic acid: Mix 10g of poloxamer 188 and 10g of food-grade polyglutamic acid, raise the temperature to 130-135°C and grind for 30min, and add an equal weight of Boil water, reflux and keep stirring for 10 minutes, then add 1g hydrogenated castor oil and 0.5g polydiallyl dimethyl ammonium chloride, continue to reflux and keep stirring for 30 minutes, and the resulting mixtur...
Embodiment 2
[0023] Preparation of preparation aids: Add 1g of sorbitol and 0.5g of hydrogenated palm oil to 5g of microcrystalline cellulose, raise the temperature to 55-60°C and grind for 15 minutes, then transfer to an environment of 0-5°C to seal and stand for 1h, then raise the temperature Heat and grind at 70-75°C for 5 minutes, then add 15g of poloxamer / polyglutamic acid and 3g of pregelatinized hydroxypropyl starch / citric acid, continue to heat and grind for 15 minutes, and cool the resulting mixture to room temperature naturally. The micro pulverizer makes fine powder.
[0024] Preparation of poloxamer / polyglutamic acid: Mix 5 g of poloxamer 188 and 5 g of food-grade polyglutamic acid, raise the temperature to 130-135 °C and grind for 30 minutes, and add an equal weight of Boil water, reflux and keep stirring for 10min, then add 0.5g hydrogenated castor oil and 0.5g polydiallyl dimethyl ammonium chloride, continue to reflux and keep stirring for 30min, and the resulting mixed solu...
Embodiment 3
[0040] The methods described in Example 1, Example 2, Comparative Example 1, Comparative Example 2, and Comparative Example 3 were used to entrap volatile oil respectively, and the immediate inclusion rate and preparation stability after inclusion of volatile oil were measured. The results are shown in Table 1.
[0041] Table 1 volatile oil inclusion rate and preparation stability
[0042] Measurement items
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