Preparation method of folic acid

A folic acid, acid-soluble technology, applied in the field of medicine, can solve the problems of large water consumption and waste water, and achieve the effects of high comprehensive yield, cost reduction, and waste water volume reduction.

Inactive Publication Date: 2017-09-15
NANJING JINHAO MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Both of the above two methods for preparing folic acid use water as a solvent, and the water consumption is large, resulting in a lot of waste water

Method used

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  • Preparation method of folic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method for folic acid, specifically comprising the following steps:

[0027] (1) Add 18g of 1,1,3-tribromoacetone into 600mL of ethanol solution, stir and heat to 55°C;

[0028] (2) After the 1,1,3-tribromoacetone is completely dissolved, continue to add 10 g of p-aminobenzoyl-L-glutamic acid and stir until completely dissolved to obtain the first reaction solution;

[0029] (3) Add 120 g of water to another reaction flask, weigh 12 g of 2,4,5-triamino-6-hydroxypyrimidine sulfate in batches, and adjust the pH to 8 with saturated sodium carbonate to 2 , 4,5-triamino-6-hydroxypyrimidine sulfate is completely dissolved to obtain the second reaction solution;

[0030] (4) The second reaction solution is added in batches to the first reaction solution, and the insulation reaction is carried out for 5 hours;

[0031] (5) After the reaction is completed, carry out suction filtration to obtain the folic acid crude product;

[0032] (6) Add the folic acid crude ...

Embodiment 2

[0043] A preparation method for folic acid, specifically comprising the following steps:

[0044] (1) Add 14.74g of 1,1,3-tribromoacetone into 600mL of ethanol solution, stir and heat to 50°C;

[0045] (2) After the 1,1,3-tribromoacetone is completely dissolved, continue to add 10.65 g of p-aminobenzoyl-L-glutamic acid and stir until completely dissolved to obtain the first reaction solution;

[0046] (3) Add 90 g of water to another reaction flask, weigh 9.49 g of 2,4,5-triamino-6-hydroxypyrimidine sulfate in batches, and adjust the pH to 8.5 with saturated sodium carbonate until 2,4,5-triamino-6-hydroxypyrimidine sulfate is completely dissolved to obtain the second reaction solution;

[0047] (4) The second reaction solution is added in batches to the first reaction solution, and the insulation reaction is carried out for 6 hours;

[0048] (5) After the reaction is completed, carry out suction filtration to obtain the folic acid crude product;

[0049] (6) Add the folic a...

Embodiment 3

[0057] A preparation method for folic acid, specifically comprising the following steps:

[0058] (1) Add 20.63g of 1,1,3-tribromoacetone into 600mL of ethanol solution, stir and heat to 40°C;

[0059] (2) After the 1,1,3-tribromoacetone is completely dissolved, continue to add 5.33 g of p-aminobenzoyl-L-glutamic acid and stir until completely dissolved to obtain the first reaction solution;

[0060] (3) Add 144g of water in another reaction flask, weigh 14.23g of 2,4,5-triamino-6-hydroxypyrimidine sulfate in batches, and adjust the pH to 7.5 with saturated sodium carbonate until 2,4,5-triamino-6-hydroxypyrimidine sulfate is completely dissolved to obtain the second reaction solution;

[0061] (4) adding the second reaction solution in batches to the first reaction solution, and performing an insulation reaction for 8 hours;

[0062] (5) After the reaction is completed, carry out suction filtration to obtain the folic acid crude product;

[0063] (6) Add the folic acid crude ...

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a preparation method of folic acid, comprising the steps of (1) adding 1,1,3-tribromoacetone into ethanol solution, and stirring under heating; (2) dissolving the 1,1,3-tribromoacetone completely, continuing to add p-aminobenzoyl-L-glutamic acid, and stirring until full dissolution to obtain first reaction liquid; (3) dissolving 2,4,5-triamino-6-hydroxypyrimidine sulfate in water, and adjusting pH with saturated sodium carbonate until the 2,4,5-triamino-6-hydroxypyrimidine sulfate is fully dissolved to obtain second reaction liquid; (4) adding the second reaction liquid to the first reaction liquid, and allowing reacting under held temperature; (5) after reacting, performing suction filtering to obtain crude folic acid; (6) acid-dissolving the crude folic acid, alkali-dissolving, and refining to obtain finished folic acid. The preparation method of folic acid has the advantages that the defect that the prior art has high water consumption is changed from the purpose of saving resources and the integrated water saving is up to 40% and above.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of folic acid. Background technique [0002] Folic acid, also called vitamin B9, is a water-soluble vitamin widely used in feed, medicine and food. It is understood that the synthesis of folic acid has the following several methods: [0003] 1, the preparation route one of folic acid [0004] From 2,4,5-triamino-6-hydroxypyrimidine, α, β-dibromopropionaldehyde and p-aminobenzoyl-L-glutamic acid condensation preparation. The method reacts in the acetic acid-sodium acetate buffer solution to obtain the folic acid crude product, and then refines to obtain two molecules of folic acid (Coy W.Waller.Brian L Hutchings Synthesis of Pteroylglutamic Acid (Liver L.casci Factor) and Pteroic Acid.I(J)J . Am. Chem. Soc., 1984, 70:19-22). [0005] 2. Folic acid preparation route 2 [0006] This route uses 2,4,5-triamino-6-hydroxypyrimidine, hydroxymalondia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D475/04
CPCC07D475/04
Inventor 吴建中
Owner NANJING JINHAO MEDICAL TECH CO LTD
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