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Application of curcumin analogue CD35 to preparation of medicine for treating breast cancer

A curcumin analog, CD35 technology, applied in the medical field, can solve the problem that curcumin CD35 is blank

Inactive Publication Date: 2017-09-22
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, academic reports on curcumin analogues in cancer have also been mentioned, but the specific application of curcumin CD35 in breast cancer is still blank

Method used

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  • Application of curcumin analogue CD35 to preparation of medicine for treating breast cancer
  • Application of curcumin analogue CD35 to preparation of medicine for treating breast cancer
  • Application of curcumin analogue CD35 to preparation of medicine for treating breast cancer

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Experimental program
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Embodiment Construction

[0026] The present invention is further described below in conjunction with embodiment.

[0027] The application of a kind of curcumin analogue CD35 provided by the present invention in the preparation treatment breast cancer medicine, the chemical formula of curcumin analogue CD35 is: 1-(4-hydroxyl-3-methoxyphenyl)-5-(2- Nitrophenyl)-1,4-pentadien-3-one, the structural formula is: .

[0028] 1. In vitro experiment of curcumin analogue CD35 inhibiting breast cancer cell metastasis;

[0029] 1.1 Experimental materials;

[0030] Experimental cells: breast cancer MDA-MB-231 cells, breast cancer Hs 578T cells, culture flasks with DMEM medium containing 10% FBS (100 µl / mL penicillin, 100 µl / mL streptomycin, 2 mmol / L L- Glutamine) were cultured in a 37°C, 5% CO2 incubator, routinely digested with 0.125% trypsin, and passaged.

[0031] Experimental drugs: curcumin, curcumin analog CD35;

[0032] Other experimental materials: cryopreservation tube, DMEM culture medium (Gibco), 0...

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Abstract

The invention relates to application of a curcumin analogue CD35 to preparation of a medicine for treating breast cancer. A chemical formula of the curcumin analogue CD35 is 1-(4-hydroxy-3-methoxyphenyl)-5-(2-nitrophenyl)-1,4-pentadiene-3-one, and a structural formula is shown in the description; the curcumin analogue CD35 is used for down-regulating the expression of YAP proteins in a Hippo path to inhibit the autophagy of breast cancer cells, so as to inhibit the energy metabolism of the breast cancer cells. The curcumin analogue CD35 provided by the invention has remarkable advantages of improving the targeting ability of the medicine for treating the breast cancer and reducing the toxic and side effects of the medicine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new medical application of curcumin analogue CD35. Background technique [0002] Breast cancer is one of the most common malignant tumors in women worldwide. Distant metastasis of breast cancer is an important cause of death in breast cancer patients. The incidence of breast cancer in the world is increasing at a rate of about 2% every year. It is estimated that by 2030, the number of cases and deaths in the world will reach 2.64 million and 1.7 million, respectively. At present, the clinical treatment of breast cancer is still based on surgical resection, supplemented by radiotherapy, chemotherapy and immunotherapy. Surgical treatment plays a limited role in locoregional recurrence and distant metastatic events, which are closely related to survival. Although the cure rate of radiotherapy and chemotherapy for breast cancer has been improved to a certain extent, traditional breast ...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P35/00
CPCA61K31/12
Inventor 陶哲影王丽花陈通克杨淋钧韩磊韩黎杰
Owner WENZHOU MEDICAL UNIV
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