Application of lactalbumin-oleic acid composite to preparation of medicines for restraining energy metabolism of tumor cells

A technology of oleic acid complex and lactalbumin, which is applied in the direction of antineoplastic drugs, drug combinations, peptide/protein components, etc., can solve problems that have not been evaluated, and achieve the effect of inhibiting energy metabolism
CN110478475AInactive Publication Date: 2019-11-22CHINA AGRI UNIV
1 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA AGRI UNIV
Publication Date
2019-11-22
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an application of a lactalbumin-oleic acid composite to preparation of medicines for restraining energy metabolism of tumor cells, and finds that alpha-LA-OA can resist the glycolysis process of tumor cells and reduce the consumption of oxygen by an aerobic respiration process of a mitochondrion and the generation amount of ATP. In addition, the invention further finds thatthe alpha-LA-OA can reduce generation of ATP in an HepG2 cell glucose metabolism way, so that the effect of restraining energy metabolism of tumor cells can be achieved; an HepG2 tumor cell model isused for confirming that the alpha-LA-OA can notably promote expression of mTORC2 target protein Rictor, mSin1 and Ser473-Akt, and the expression amount of various enzymes in the glycolysis way can benotably reduced. The alpha-LA-OA can activate an mTORC2 signal route, and can restrain activity of key enzymes in the glucose metabolism way, so as to reduce the energy metabolism for restraining tumor cells, by ATP.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of biotechnology, and particularly relates to the application of lactalbumin-oleic acid complex (α-LA-OA) in the preparation of drugs for inhibiting energy metabolism of tumor cells. Background technique

[0002] Cancer is a major public health problem worldwide. Although research on cancer prevention and treatment has progressed rapidly in recent years, its incidence remains high. According to reports, the global incidence of cancer increased by 28% from 2006 to 2016. Therefore, the development of new and effective anti-tumor drugs is still a research hotspot, and molecularly targeted drugs for tumor cells have received extensive attention.

[0003] α-lactalbumin-oleic acid complex (α-LA-OA) has a good antitumor effect, and its selective killing of tumor cells without affecting the activity of healthy differentiated cells not only in human glioblastoma and bladder cancer Validated in a mouse model of , and in patie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More