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Application of phthalide compound used for preparing medicine to replace/help hyperbaric oxygen therapy to improve tissue hypoxia

A technology of compounds and phthalides, which is applied in the field of medicine and can solve fatal problems

Inactive Publication Date: 2017-09-22
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, hyperbaric oxygen therapy may cause considerable side effects, including barotrauma, decompression sickness, and oxygen toxicity, because the subject inhales high-concentration oxygen under high pressure and rapid pressure changes between tissues. If the operation is not performed properly, it may even be fatal risks of

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  • Application of phthalide compound used for preparing medicine to replace/help hyperbaric oxygen therapy to improve tissue hypoxia
  • Application of phthalide compound used for preparing medicine to replace/help hyperbaric oxygen therapy to improve tissue hypoxia
  • Application of phthalide compound used for preparing medicine to replace/help hyperbaric oxygen therapy to improve tissue hypoxia

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[0028]The technical solutions of the present invention are further described below through specific examples, which do not represent limitations to the protection scope of the present invention. Some non-essential modifications and adjustments made by others according to the concept of the present invention still belong to the protection scope of the present invention.

[0029] In order to understand the technical content, features, and advantages of the present invention more clearly, the following examples are given in detail with reference to the drawings, but the following examples are not intended to limit the present invention.

[0030] The phthalide compound of the present invention is any compound comprising the molecular structure characteristics of phthalide, such as Z-butenylphthalide (Z-butylidenephthalide) ( Figure 7A ), Z-ligustilide ( Figure 7B ), senkyunolide A (senkyunolide A) ( Figure 7C ), senkyunolide H (senkyunolide H) ( Figure 7D ), senkyunolide I ...

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Abstract

The invention relates to an application of a phthalide compound used for preparing a medicine to replace / help hyperbaric oxygen therapy to improve tissue hypoxia. The phthalide compound has the functions of promoting the oxygen release ability of hemoglobin in blood and accordingly promoting the tissue oxygen content degree, and when the phthalide compound replaces or cooperates with the hyperbaric oxygen therapy to be applied on a patient, common side effects, such as barotrauma, decompression disease and oxygen poisoning, of the traditional hyperbaric oxygen therapy can be avoided. The phthalide compound is used for replacing / helping 2,3-diphosphoglycerate to adjust and lower the affinity for oxygen of the hemoglobin and promoting the efficiency, namely releasing the oxygen to histiocytes, of the hemoglobin, so that the cell oxygen content can reach and maintain a normal range.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of a phthalide compound for preparing a medicine for replacing / assisting hyperbaric oxygen therapy to improve tissue hypoxia. Background technique [0002] Hemoglobin (Hb for short) is a protein in red blood cells that is used to carry and transport oxygen. Cells and tissues can obtain enough oxygen to maintain the normal physiological functions of various organs and surrounding cells and tissues. [0003] Normal adult hemoglobin is a tetramer α composed of four subunits, α1, α2, β1, and β2 2 beta 2 In each subunit, the secondary and tertiary structures of each subunit are stabilized by intermolecular forces such as intra-subunit hydrogen bonds, and the In addition, inter-subunit hydrogen bonds can be formed, so that the aforementioned four subunits can jointly form a quaternary structure. [0004] The quaternary structure of hemoglobin has two different configurations: the rela...

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Application Information

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IPC IPC(8): A61K31/365A61K31/6615A61P7/00A61P39/00
CPCA61K31/365A61K31/6615A61K2300/00
Inventor 王家蓁陈韦任
Owner SUN YAT SEN UNIV
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