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New Pharmaceutical Application of Naozhenning Preparation

A technology of brain shock and preparations, applied in the direction of drug combination, pill delivery, medical formula, etc.

Active Publication Date: 2021-11-19
SHANXI ZHENDONG ANXIN BIOLOGICAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no FDA-approved drugs that reduce cell death after brain injury

Method used

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  • New Pharmaceutical Application of Naozhenning Preparation
  • New Pharmaceutical Application of Naozhenning Preparation
  • New Pharmaceutical Application of Naozhenning Preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1: Brain Zhenning Extract

[0098] Brain Zhenning extract is a refined product made according to the prescription disclosed in the patent No. 931007410.

[0099] Prescription: Angelica 200g, Rehmannia glutinosa 200g, Moutan bark 150g, Chuanxiong 150g, Dilong 150g, Salvia miltiorrhiza 375g, Poria cocos 250g, tangerine peel 250g, Zhuru 250g, fried jujube kernel 250g, Baiziren 250g.

[0100] Preparation method: the above eleven flavors, angelica, moutan cortex, chuanxiong, and tangerine peel are distilled to extract volatile oil, then add other medicinal materials to extract with water, filter, and concentrate into a thick paste to obtain Zhenzhenning extract.

Embodiment 2

[0101] Embodiment 2: Naozhenning Granules

[0102] Sucrose-free Naozhenning granules were prepared according to standard WS3-B-3312-98-1.

[0103] Prescription: Angelica 200g, Rehmannia glutinosa 200g, Moutan bark 150g, Chuanxiong 150g, Dilong 150g, Salvia miltiorrhiza 375g, Poria cocos 250g, tangerine peel 250g, Zhuru 250g, fried jujube kernel 250g, Baiziren 250g.

[0104] The above eleven flavors, Angelica, Moutan Cortex, Chuanxiong, and Tangerine Peel are distilled to extract volatile oils, and the distilled aqueous solution is collected in a separate device; the dregs and the other seven flavors such as Salvia Miltiorrhiza are decocted twice, each time for 1.5 hours, and the decoctions are combined and filtered. Combine the filtrate with the above aqueous solution, concentrate to a clear paste with a relative density of 1.35-1.38 (55°C), add appropriate amount of sucrose and dextrin, granulate, dry, add the above-mentioned volatile oil, mix well, and make 1000g; Ningyouta...

Embodiment 3

[0105] Embodiment 3: Naozhenning Capsules

[0106] Prescription: Angelica 220g, Rehmannia glutinosa 210g, Moutan bark 160g, Chuanxiong 140g, Dilong 130g, Salvia miltiorrhiza 330g, Poria cocos 260g, tangerine peel 260g, Zhuru 260g, fried Suanzaoren 160g, Baiziren 160g.

[0107] Preparation method: the above eleven flavors, angelica, peony bark, chuanxiong, tangerine peel are distilled to extract volatile oil, and then add other medicinal materials for water extraction. After water extraction, use 80% ethanol to sink twice, concentrate into a thick paste, add appropriate amount of Mix the starch evenly, granulate, dry and granulate, add the obtained volatile oil, and stir evenly to prepare 200 Naozhenning capsules, each containing 0.4g.

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Abstract

The invention relates to a new pharmaceutical application of Naozhenning preparation. As a traditional Chinese medicine preparation, Naozhenning is widely used in the treatment of clinical concussion patients. The present invention finds that when Naozhenning is applied to the traumatic brain injury model of mice, the cell death in the cortex and hippocampus is less than that of the blank group, and the degree of cortical defect is lighter than that of the blank group. At the same time, Brain Zhenning can protect cortical axons after injury, and also protect dendritic branches and the total length of dendritic branches to a certain extent. Tests have shown that Brain Zhenning has a neuroprotective effect on traumatic brain injury.

Description

technical field [0001] The invention relates to a new medical application of a drug, in particular to a new medical application of a marketed drug, Zhenningning preparation. Background technique [0002] Traumatic Brain Injury (TBI) is an important cause of disability in people under the age of 45. In North America and Europe, the incidence of traumatic brain injury is about 500 / 100,000 people per year. The World Health Organization predicts that between 2000 and 2020, the number of road traffic deaths (most of which are due to traumatic brain injuries) will double and continue to increase, mainly in low-middle-income countries in a traffic accident. By 2020, traumatic brain injury will become the third leading cause of disability and death worldwide (WHO, 2009). [0003] On the other hand, acute and chronic risk factors related to concussions caused by sports in adolescents also deserve attention. Accumulating evidence shows that patients with a history of multiple mino...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K9/20A61P25/28A61K35/62
CPCA61K9/2059A61K35/62A61K36/076A61K36/14A61K36/232A61K36/236A61K36/537A61K36/65A61K36/71A61K36/725A61K36/752A61K36/804A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 李昆陈锦辉朱平秦正国范玛莉刘海霞
Owner SHANXI ZHENDONG ANXIN BIOLOGICAL PHARM CO LTD
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