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Traditional Chinese medicine composition for treating Alzheimer's disease

A technology for Alzheimer's disease and a composition, which is applied in the field of medicine and can solve the problems of small dosage and unsuitable long-term application.

Active Publication Date: 2017-09-22
NANJING TONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dose should be small and not suitable for long-term application

Method used

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  • Traditional Chinese medicine composition for treating Alzheimer's disease
  • Traditional Chinese medicine composition for treating Alzheimer's disease

Examples

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Embodiment 1

[0013] Embodiment 1: Take 40 parts of Magnolia japonica; 50 parts of vines without a genus; 40 parts of Astragalus; 60 parts of Codonopsis Radix; 25 parts of Salvia miltiorrhiza; 15 parts of Shichangpu; 5 parts of Turmeric; 25 parts of Scutellaria chinensis; 30 parts of Angelica sinensis; 10 parts of Radix Polygoni; Essence package, standby; filter the aqueous solution extracted by water calamus, turmeric, chuanxiong, and angelica by steam distillation to obtain the distilled aqueous solution of calamus, turmeric, chuanxiong, and angelica, and heat and concentrate to obtain calamus, turmeric, chuanxiong, The water concentrate after the distillation of Angelica sinensis is for standby use; keep the medicinal residues of Acorus sinensis, Curcuma Radix, Rhizoma Chuanxiong, and Angelica sinensis extracted by steam distillation, for subsequent use; the obtained medicinal residues of Acorus sinensis, Curcuma Radix, Rhizoma Chuanxiong, and Angelica sinensis are extracted by steam dist...

Embodiment 2

[0014] Embodiment 2: take 60 parts of Magnolia japonica; 30 parts of vines without vine; 60 parts of Astragalus; 40 parts of Codonopsis Radix; 45 parts of Salvia miltiorrhiza; 5 parts of Shichangpu; 15 parts of Turmeric; 45 parts of Scutellaria officinalis; 10 parts of Angelica sinensis; 20 parts of Polygala Radix; 5 parts of Licorice, the preparation method comprises the following steps: take calamus, turmeric, chuanxiong, angelica, extract them by steam distillation, extract volatile oil therefrom, use cyclopaste Essence package, standby; filter the aqueous solution extracted by water calamus, turmeric, chuanxiong, and angelica by steam distillation to obtain the distilled aqueous solution of calamus, turmeric, chuanxiong, and angelica, and heat and concentrate to obtain calamus, turmeric, chuanxiong, The water concentrate after the distillation of Angelica sinensis is for standby use; keep the medicinal residues of Acorus sinensis, Curcuma Radix, Rhizoma Chuanxiong, and Ange...

Embodiment 3

[0015] Embodiment 3: take 50 parts of Magnolia japonica; 40 parts of vines without a grandfather; 50 parts of Astragalus; 50 parts of Codonopsis Radix; 35 parts of Salvia miltiorrhiza; 10 parts of Shichangpu; 10 parts of Turmeric; 35 parts of Scutellaria chinensis; 20 parts of Angelica sinensis; 15 parts of Polygala Radix; 10 parts of Licorice, the preparation method comprises the following steps: take calamus, turmeric, chuanxiong and angelica, carry out steam distillation extraction, extract volatile oil therefrom, use cyclopaste Essence package, standby; filter the aqueous solution extracted by water calamus, turmeric, chuanxiong, and angelica by steam distillation to obtain the distilled aqueous solution of calamus, turmeric, chuanxiong, and angelica, and heat and concentrate to obtain calamus, turmeric, chuanxiong, The water concentrate after the distillation of Angelica sinensis is for standby use; keep the medicinal residues of Acorus sinensis, Curcuma Radix, Rhizoma Chu...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating Alzheimer's disease. The traditional Chinese medicine composition is prepared by extracting the following raw material medicines in parts by weight: 40-60 parts of lirianthe delavayi, 30-50 parts of filliform cassytha herb, 40-60 parts of astragalus, 40-60 parts of codonopsis pilosula, 25-45 parts of salvia miltiorrhiza, 5-15 parts of rhizoma acori graminei, 5-15 parts of radix curcumae, 10-30 parts of white paeony root, 5-15 parts of ligusticum wallichii, 10-20 parts of eucommia ulmoides, 25-45 parts of caulis spatholobi, 10-30 parts of angelica sinensis, 10-20 parts of polygala tenuifolia and 5-15 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention achieves the effects of shortening morris water maze incubation period, prolonging the passive avoidance test incubation period and reducing the number of errors; and for model animal brain tissues dosed with the traditional Chinese medicine composition, the SOD (Superoxide Dismutase) activity is increased, and the content of MDA (Methylene Dioxyamphetamine) is reduced. The study proves that the traditional Chinese medicine composition disclosed by the invention has the curative effects of improving dementia model brain tissue injuries and improving memory functions.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for treating senile dementia and a preparation method and application thereof. Background technique [0002] Alzheimer's disease is a progressive neurodegenerative disease with an insidious onset. Clinically, it is characterized by generalized dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and changes in personality and behavior. The etiology is still unknown. Those with onset before the age of 65 are called Alzheimer's disease; those with onset after the age of 65 are called senile dementia. The disease may be a heterogeneous group of diseases that develop under the influence of multiple factors, including biological and psychosocial factors. From the current research, there are more than 30 possible factors and hypotheses for the disease, such as f...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K47/69A61P25/28
CPCA61K36/232A61K36/236A61K36/344A61K36/46A61K36/481A61K36/484A61K36/486A61K36/537A61K36/54A61K36/575A61K36/65A61K36/69A61K36/71A61K36/888A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 浩健周勤文陈家进
Owner NANJING TONGRENTANG PHARM CO LTD
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