A kind of automatic decellularization system and decellularization method
A decellularization and container technology, applied in the decellularization field, can solve the problems of pollution, restricting the large-scale production and application of biological materials, and high labor costs
Active Publication Date: 2020-09-18
SHAANXI RUISHENG BIOTECH
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Problems solved by technology
[0003] The existing decellularization technology is mainly completed by shaking the shaker in the reaction vessel. In the large-scale production of biological materials, there are many manual interventions, which leads to high labor costs. Moreover, the decellularization process requires rigorous research and development. Production conditions, when there are many manual interventions, it is easy to cause pollution, which makes it difficult to guarantee the quality of the decellularized biological materials obtained, which limits the large-scale production and application of biological materials
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[0040] An automatic decellularization system and a decellularization method provided by the embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
[0041] On the one hand, the embodiment of the present invention provides an automatic decellularization system, see figure 1 ,include:
[0042] Decellularization equipment, the decellularization equipment includes a decellularization container 1 and an oscillating device 2, the oscillating device 2 is located below the decellularization container 1;
[0043] A decellularization reagent supply device 3 and a waste liquid discharge device 4 respectively communicated with the decellularization container 1;
[0044] A control device 5, the control device 5 is used to control the opening and closing of the oscillation device 2, and control the decellularization reagent supply device 3 to supply the decellularization reagent into the decellularization container 1, and control...
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The invention relates to the technical field of decellularization and particularly relates to an automatic decellularization system and method. By automatic control, the artificial intervention in the decontamination of the biomaterial is reduced and conditions are created for the large-scale production and application of the biomaterial. The automatic decellularization system comprises a decellularization device comprising a decellularization container and an oscillating device located below the decellularization container, a decellularization regent supplying device and a waste liquid discharge device respectively connected to the decellularization container, and a controller for controlling starting and stopping of the oscillating device, controlling the decellularization regent supplying device so that the decellularization regent is fed into the decellularization container by the decellularization regent supplying device, and controlling the waste liquid discharge device so that the waste liquid discharge device discharges the liquid in the decellularization container.
Description
technical field [0001] The invention relates to the technical field of decellularization, in particular to an automatic decellularization system and a decellularization method. Background technique [0002] In recent years, with the in-depth research on the decellularization technology of biomaterials, a biomaterial substitute with good biocompatibility, low immunogenicity, and good repair effect after implantation has been provided. Among them, biomaterials such as pigs Animal membrane tissues such as the small intestine and bovine pericardium retain the three-dimensional structure of the original tissue after decellularization, and its main component is collagen with low immunogenicity, making it the best substitute for human tissue transplantation. [0003] The existing decellularization technology is mainly completed by shaking the shaker in the reaction vessel. In the large-scale production of biological materials, there are many manual interventions, which leads to hig...
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IPC IPC(8): A61L27/36A61L31/00
CPCA61L27/3625A61L27/3629A61L27/3691A61L31/005A61L2430/40
Inventor 王红刚韩卫东米维雷文诚
Owner SHAANXI RUISHENG BIOTECH