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Method for screening specific circular RNA (ribonucleic acid) of triple-negative breast cancer

A technology for triple-negative breast cancer, screening method, applied in the direction of biochemical equipment and methods, determination/inspection of microorganisms, etc.

Active Publication Date: 2017-10-17
重庆鼎晶医学检验所有限公司
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Problems solved by technology

[0004] So, can circular RNA become an entry point for the diagnosis and treatment of triple-negative breast cancer? In the prior art, research on triple-negative breast cancer-specific circular RNA is still blank

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  • Method for screening specific circular RNA (ribonucleic acid) of triple-negative breast cancer
  • Method for screening specific circular RNA (ribonucleic acid) of triple-negative breast cancer
  • Method for screening specific circular RNA (ribonucleic acid) of triple-negative breast cancer

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Embodiment Construction

[0116] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0117] A screening method for triple-negative breast cancer-specific circular RNA, the method comprising the following 5 steps:

[0118] (1) A number of sera from female patients with triple-negative breast cancer were selected as the experimental group A; normal female sera equal to the number of the experimental group A were selected as the control group B. In this embodiment, the serum of 15 female patients with triple-negative breast cancer was analyzed, and the serum of 15 normal female patients was used as a control. Select the dissolution and amplification curves in some experimental groups and control groups in the accompanying drawings, such as Figure 1-8 as shown, figure 1 is the amplification curve of experimental group 1; figure 2 It is the dissolution curve figure of experimental group 1; image 3 is the amplificati...

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Abstract

The invention discloses a method for screening specific circular RNA (ribonucleic acid) of triple-negative breast cancer. The method includes comparing circular gene expression of triple-negative breast cancer plasma samples and normal comparison groups by the aid of 70 parts of specific circular RNA of breast cancer; screening the specific circular RNA to obtain the circular RNA with functions of specifically obviously expressing the triple-negative breast cancer. The specific circular RNA is used as primers. The method has the advantage that results obtained by the aid of the method have important significance on triple-negative breast cancer diagnosis and treatment.

Description

technical field [0001] The invention relates to a screening method for tumor-specific circular RNA, in particular to a screening method for triple-negative breast cancer-specific circular RNA. Background technique [0002] Circular RNA (circular RNA) is a type of endogenous non-coding RNA different from linear RNA. It is a closed circular RNA molecule formed by back splicing and belongs to the non-coding RNA family. It is characterized by conservation, stability, specificity, and high content. It can be used as a microRNA sponge to regulate the activity of target miRNAs, and participate in the regulation of gene transcription and protein production. It has gradually become a new star in the non-coding RNA regulatory network. With the further advancement of RNA research technology, researchers have found that circular RNA plays an important role in the occurrence and development of cardiovascular system diseases, nervous system diseases, prion protein diseases and other disea...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6811C12Q1/6886C12Q2600/178C12Q2531/113C12Q2563/107
Inventor 李丽仙辇伟奇林昌海张海伟唐超易琳冉静何永鹏唐万燕
Owner 重庆鼎晶医学检验所有限公司
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