A kind of preparation method of hemostatic gel dressing containing zeolite

A technology of hemostatic gel and zeolite, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of patient pain, increase the difficulty of cleaning wounds for doctors, and burn wounds, shorten the hemostasis time, optimize the pore-forming effect, and promote communication. The effect of linked reactions
CN107261199BActive Publication Date: 2020-04-21NORTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NORTHWEST UNIV
Publication Date
2020-04-21

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Abstract

The invention relates to a method for preparing a porous hemostatic gel dressing based on human-like collagen and zeolite. The mass ratio of zeolite to human-like collagen is 1:10-1:20, adding an appropriate amount of zeolite to the LHC solution, adding inorganic salts and Stir the complex cross-linking agent β-diimine zinc complex and 1,2,7,8-diepoxyoctane evenly, adjust the pH value of the solution to acidic conditions, and place it in a 40-80°C water bath to maintain 0.5- After 5 hours, high-temperature steam treatment and water washing are repeated twice to remove salt and cross-linking agent residues. After drying and Co-60 sterilization, a zeolite-containing hemostatic gel dressing can be obtained. In addition to the good breathability, anti-adhesion and rapid hemostatic effect of this material, the gel medium itself disperses the zeolite particles, which greatly alleviates the exothermic problem caused by the zeolite during the hemostatic effect. Compared with the situation without introducing zeolite gel, the hemostasis time is significantly shortened to 15-25s on average.
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Description

technical field

[0001] The invention relates to a preparation method of a zeolite-containing hemostatic gel dressing, which belongs to the technical field of medical hemostatic materials. Background technique

[0002] Zeolite is a general term for porous hydrous aluminosilicate crystals with a framework structure. Zeolite has a strong skeleton structure, and there are large-volume voids such as cavities and channels inside. At the same time, there are many micropores and channels of uniform size inside the crystal lattice, and the volume can account for more than 50% of the volume of zeolite. The micropores and channels are interconnected, giving the zeolite a large surface area. Therefore, zeolite has high water absorption rate and water absorption capacity. When zeolite is used in hemostatic materials, it can absorb water in blood, concentrate platelets and coagulation factors, and achieve the purpose of hemostasis. The use of zeolite hemostatic dressings has been widely...

Claims

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