A kind of agarose antibacterial dressing based on macromolecule quaternary ammonium salt grafting and preparation method thereof

A technology of agarose and quaternary ammonium salt, applied in the field of antibacterial materials, can solve the problems of maintaining antibacterial function, difficult and unfavorable use of antibacterial agents, and achieve the effects of inhibiting bacterial growth, promoting wound healing, and accelerating wound healing.

Active Publication Date: 2020-04-24
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For medical purposes such as antifouling on the surface of medical devices, antimicrobial agents in liquid form are not conducive to maintaining the antibacterial function effectively for a long time
For wound care and wound healing such as scalds and burns, antibacterial agents in liquid form are even more difficult to use

Method used

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  • A kind of agarose antibacterial dressing based on macromolecule quaternary ammonium salt grafting and preparation method thereof
  • A kind of agarose antibacterial dressing based on macromolecule quaternary ammonium salt grafting and preparation method thereof
  • A kind of agarose antibacterial dressing based on macromolecule quaternary ammonium salt grafting and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 15 grams of agarose and 500 milliliters of distilled water into a three-necked flask with a volume of 1 liter equipped with mechanical stirring, and then heat the agarose suspension in an oil bath at 95 degrees until completely dissolved. Under nitrogen protection, 3.3 grams of potassium persulfate and 125 milliliters of 80 wt % aqueous solution of methacryloyloxyethyltrimethylammonium chloride were sequentially added to the reaction solution. The mixture was stirred in an oil bath at 90° C. for 6 hours, then poured into a beaker, and cooled naturally to room temperature to form a gel-like solid. The obtained solid is repeatedly soaked in distilled water to obtain the invented macromolecular quaternary ammonium salt grafted agarose, which is reshaped through heating and dissolving, mold casting, and cooling molding to prepare the required antibacterial dressing.

Embodiment 2

[0030] Add 15 grams of agarose and 500 milliliters of distilled water into a three-necked flask with a volume of 1 liter equipped with mechanical stirring, and then heat the agarose suspension in an oil bath at 95 degrees until completely dissolved. Under nitrogen protection, 3.3 grams of potassium persulfate and 62.5 milliliters of 80 wt % aqueous solution of methacryloyloxyethyltrimethylammonium chloride were sequentially added to the reaction liquid. The mixed solution was stirred in an oil bath at 90° C. for 6 hours, then poured into a beaker, and purified to obtain the invented antibacterial dressing.

Embodiment 3

[0032] 15 g of agarose and 500 ml of distilled water were added to a three-neck flask with a volume of 1 liter equipped with mechanical stirring, and then the agarose suspension was heated in an oil bath at 95° C. until completely dissolved. Under nitrogen protection, 3.3 grams of potassium persulfate and 125 milliliters of 80 wt % aqueous solution of methacryloyloxyethyltrimethylammonium chloride were sequentially added to the reaction solution. The mixture was stirred in an oil bath at 80° C. for 6 hours, then poured into a beaker, and purified to obtain the invented antibacterial dressing.

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Abstract

The invention relates to a macromolecule quaternary ammonium salt-grafted agarose antibacterial dressing and a preparation method thereof. The method comprises adding a polymer containing an agarbiose unit into hot water, carrying out stirring until complete dissolution, adding an appropriate amount of an initiator potassium persulfate and a monomer methacryloyloxyethyl trimethyl ammonium chloride into the solution, stirring the reaction solution in a nitrogen atmosphere at 90 DEG C for 6h, cooling the solution to the room temperature, and fixing and immersing the gel in distilled water to remove impurities. The macromolecule quaternary ammonium salt-grafted agarose has good biocompatibility and can form gel-type antibacterial dressing through heating dissolution, mold casting and curing. In-vitro antibacterial test results show that the antibacterial dressing can effectively inhibit the growth of bacteria and kill bacteria attached to the surface of the biomedical material. In-vivo experiment proves that the macromolecule quaternary ammonium salt-grafted agarose antibacterial dressing can significantly cure Staphylococcus aureus infection and promote wound healing in rats.

Description

technical field [0001] The invention belongs to the field of antibacterial materials, and relates to an agarose antibacterial dressing based on macromolecule quaternary ammonium salt grafting and a preparation method thereof. Background technique [0002] Due to the abuse and overuse of antibiotics, some bacteria have developed drug resistance, which has directly led to an increase in treatment costs, frequent complications, and even death of patients. Therefore, it is particularly important to find novel antibacterial agents that are not prone to drug resistance. [0003] At present, quaternary ammonium salt is a kind of cationic antibacterial agent. Its antibacterial mechanism is mainly that quaternary ammonium salt contacts with bacteria and penetrates into its cell wall, and then reacts with bacterial cell membrane to destroy the cell membrane, and further action leads to the decomposition of protein and nucleic acid, intercellular substances Leakage, and finally the ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/729A61L26/00C08F251/00C08F220/34
CPCA61L26/0023A61L26/0066A61L26/008A61L2300/208A61L2300/404C08F251/00C08F220/34C08L5/12
Inventor 徐立群蔡晓燕李宁宁宁玲贵
Owner SOUTHWEST UNIV
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