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Basic fibroblast growth factor composition and preparation method thereof, hair regenerator and preparation methods and application method thereof

A technology of fibroblasts and growth factors, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of not being able to maintain the healthy state of hair for a long time, affecting the normal growth of hair, and the hair environment cannot be guaranteed. Achieve the effects of saving manpower and material resources, preventing shrinkage and degradation, and convenient operation

Active Publication Date: 2017-11-17
GUANGZHOU UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hair loss has not been fundamentally solved, and hair health cannot be maintained for a long time. The reason is that some hair follicles are atrophied or necrotic, and the environment for hair to survive cannot be guaranteed. Hair growth cannot absorb nutrients from hair follicles, and hair follicle stem cells cannot differentiate into hair keratin fibers. Therefore, it affects the normal growth of hair

Method used

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  • Basic fibroblast growth factor composition and preparation method thereof, hair regenerator and preparation methods and application method thereof
  • Basic fibroblast growth factor composition and preparation method thereof, hair regenerator and preparation methods and application method thereof
  • Basic fibroblast growth factor composition and preparation method thereof, hair regenerator and preparation methods and application method thereof

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preparation example Construction

[0083] The preparation method of the above-mentioned hair growth agent comprises the preparation step of the basic fibroblast growth factor composition, the preparation step of the growth liquid and the mixing and dissolving step;

[0084] Basic fibroblast growth factor composition preparation steps:

[0085] Material preparation steps: Weigh mannitol, hyaluronic acid and tea polyphenols according to the proportion, pour them into a mixing tank, add the first purified water, heat to 70-90°C, stir until all substances are dissolved, then cool down to 40-50°C °C to obtain the first mixed solution A;

[0086] Step of adding materials: pour the basic fibroblast growth factor into the cooled mixed solution, and stir evenly to obtain the second mixed solution A;

[0087] Filtration step: filtering the second mixed solution A through micropores;

[0088] Drying step: Put the filtered second mixed solution A into a vacuum freeze dryer, vacuum sublimation, keep the temperature at 30-...

Embodiment 1

[0110] A hair growth agent, which is prepared from a basic fibroblast growth factor composition and a growth liquid;

[0111] The basic fibroblast growth factor composition is prepared from the following components in mass percent:

[0112]

[0113] The growth solution is prepared from the following components in mass percentage:

[0114]

[0115] The preparation method of the hair growth agent comprises the steps of preparing the basic fibroblast growth factor composition, the step of preparing the growth liquid and the step of combining and packaging;

[0116] The preparation steps of the basic fibroblast growth factor composition include:

[0117] Material preparation steps: Weigh mannitol, hyaluronic acid and tea polyphenols according to the proportion, pour them into the mixing tank, add the first purified water, heat to 70°C, stir, the stirring speed is 2000r / min, and the stirring time is 15min. After all the substances are dissolved, the temperature is lowered t...

Embodiment 2

[0126] The difference between Example 2 and Example 1 is that the basic fibroblast growth factor is 0.03%, and the first purified water is 97.67%.

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Abstract

The invention discloses a basic fibroblast growth factor composition, which comprises the following components by mass percentage: 0.01-0.05% of a basic fibroblast growth factor, 1.2-3% of mannitol, 0.05-0.2% of hyaluronic acid, 0.01-0.2% of tea polyphenol and the balance of first purifying water. The invention also provides a preparation method of the basic fibroblast growth factor composition. The invention also provides a hair regenerator, and two preparation methods of the hair regenerator. The invention also provides an application method of the hair regenerator. The basic fibroblast growth factor in the composition can stimulate and promote the differentiation of hair follicle stem cells, prevents the hair follicle cell atrophia-degeneration, has restoration function of the hair follicle cells with atrophia-degeneration, gradually improves the microenvironment of hair root growth, and promotes the full nutrition supply for the root of hair and normal growth of the hair root.

Description

technical field [0001] The invention relates to the field of hair restorers, in particular to a basic fibroblast growth factor composition and a preparation method thereof, a hair restorer, a preparation method and a use method thereof. Background technique [0002] The hair loss of normal people generally falls off dozens of hairs every day. The hairs that fall out normally are the hairs in the catagen and telogen phases. Since the hairs entering the catagen phase and the hairs newly entering the growth phase are constantly in a dynamic balance, they can maintain a normal number of hairs. Pathological hair loss refers to abnormal or excessive hair loss. Excessive hair loss is caused by nutrition, air pollution, work and life pressure, and pathological reasons. Due to the above factors, some hair follicles are constantly mutated, atrophied and necrotic, and hair follicle cells grow and develop. Bad, unable to provide nutrition to the hair, which in turn leads to a shortened ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P17/14A61K36/9068
CPCA61K36/28A61K36/605A61K36/704A61K36/886A61K36/896A61K36/9068A61K38/1825A61K2300/00
Inventor 陈鲲陆祥何维陆超军陆荣徐华
Owner GUANGZHOU UNIVERSITY
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