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Use of helminthostachys zeylanica, ugonins or flavone-based compounds for the treatment or prevention of metabolic diseases

一种新陈代谢、七指蕨的技术，应用在中草药在治疗代谢疾病领域，能够解决未尽完美等问题

Inactive Publication Date: 2017-12-12
INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, for the aforementioned diseases and many other metabolic diseases, in addition to diet control and exercise are the most effective prevention and treatment methods, the existing various therapies are still not perfect and there are some things to be improved

Method used

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  • Use of helminthostachys zeylanica, ugonins or flavone-based compounds for the treatment or prevention of metabolic diseases
  • Use of helminthostachys zeylanica, ugonins or flavone-based compounds for the treatment or prevention of metabolic diseases
  • Use of helminthostachys zeylanica, ugonins or flavone-based compounds for the treatment or prevention of metabolic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0092] Example: Preparation of Ceylon seven finger fern extract

[0093] The seven-finger fern of Ceylon was purchased from the Chinese medicinal material store, and compared with the sample (NRICM-99-003) preserved in the herbarium of the National Institute of Traditional Chinese Medicine, Ministry of Health and Welfare. Get 531g of the rhizome of Ceylon seven finger fern, utilize the EtOH-H of 2.5L 2 O (1:1, 2.5L x 3) was heated under reflux for 1 hour, after which the filtrate was concentrated and freeze-dried to obtain 29 g of Heptophyllum ceylonii extract.

[0094] Embodiment: the preparation of centipede element

[0095] The obtained Hepteris ceylonis extract is separated and purified by HPLC method, and compounds such as cyperidin K, cyperidin O, cyperidin M, and cyperidin J can be obtained. In addition, for example, centipedeline L, centipedeline T and other centipedelines can be prepared by referring to known methods. Since all kinds of centipedes, for example, 21 ...

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Abstract

Disclosed is a use of Helminthostachys zeylanica, ugonins or compounds of formula (I) for the treatment or prevention of metabolic diseases comprising at least one selected from metabolic syndrome, excessive lipid accumulation, obesity, overweight, fatty liver, hepatic steatosis, hepatitis, cirrhosis, liver cancer, dyslipidemia, hyperlipidemia, hypertriglyceridemia, hyperlipoproteinemia, hypercholesterolemia, cardiovascular disease, hyperglycemia, hyperinsulinemia, diabetes mellitus type 2, insulin resistance, insulin disorder, impaired glucose tolerance and a combination thereof.

Description

technical field [0001] The present invention relates to the application of a Chinese herbal medicine in the treatment of metabolic diseases, and in particular to the application of Hepteris ceylonii and its isolated centipede and the compound of formula (I) for the treatment or prevention of metabolic diseases. Background technique [0002] Obesity and insulin imbalance are known to be associated with many diseases, such as cardiovascular disease, type 2 diabetes, fatty liver, etc. These diseases often involve abnormal lipid metabolism or abnormal carbohydrate metabolism. [0003] For example, fatty liver belongs to the initial stage of non-alcoholic fatty liver disease and is a common metabolic symptom in modern people, mainly caused by the imbalance of lipid metabolism. At present, there are quite a few clinical experiences showing that fatty liver can lead to liver cirrhosis, and is accompanied by the occurrence of steatohepatitis and liver necrosis. [0004] At present,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61K31/352A61P5/00A61P3/06A61P3/10A61P3/04A61P1/16A61P35/00A61P7/00A61P9/00A61P5/50A61K125/00
CPCA61K31/352A61K36/11A61K2300/00A61K36/12A61K2236/00A61P1/16A61P3/00A61P3/04A61P3/06A61P3/10A61P5/00A61P5/50A61P7/00A61P9/00A61P35/00
Inventor 黄琤蔡耿彰黄钰玲董明兆黄琇珍陈旺全刘慧康
Owner INST OF TRADITIONAL CHINESE MEDICINE
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