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Optical fiber field effect tube biosensor, biodetection device and method

A biosensor and effect tube technology, applied in the field of biosensors, can solve the problems of low sensor detection accuracy and reliability, single sensor mode, etc., and achieve the effect of improving accuracy and reliability

Active Publication Date: 2020-05-05
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, traditional biosensors mostly use a single sensor mode, such as optical biosensing, electrical biosensing, etc.
However, the detection accuracy and reliability of these sensors are low

Method used

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  • Optical fiber field effect tube biosensor, biodetection device and method
  • Optical fiber field effect tube biosensor, biodetection device and method
  • Optical fiber field effect tube biosensor, biodetection device and method

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Embodiment Construction

[0041] It should be pointed out that the following detailed description is exemplary and intended to provide further explanation to the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0042] It should be noted that the terminology used here is only for describing specific implementations, and is not intended to limit the exemplary implementations according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and / or combinations thereof.

[0043] The optical fiber field effect tube biosensor of the present invention comprises:

[0044] An optical fi...

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Abstract

An optical fiber field effect transistor type biosensor, and a biological detection apparatus and method are disclosed. The biosensor includes an optical fiber end surfaces and the external surface of which are coated with a conductive material, with the end surfaces and the external surface being provided with a channel and the channel dividing the conductive material into two electrodes, namely a drain electrode and a source electrode of a field effect transistor; and a graphene film disposed on the end surface of the optical fiber and connected to the drain electrode and the source electrode separately, wherein a single stranded DNA is fixed to the surface of the graphene film and adopted as a probe chain, and the other end of the probe chain is modified with fluorescent dye. Detection accuracy and stability of the biosensor are improved.

Description

technical field [0001] The invention belongs to the field of biosensors, in particular to an optical fiber field effect tube biosensor, a biodetection device and a method. Background technique [0002] Graphene is an emerging functional material. Due to its properties in optics, electricity, and ease of combining with biomolecules through π-π stacking interactions, it has attracted attention in the field of biosensor design. Adsorption of biomolecules on the graphene surface can regulate its charge transport or channel doping of charges, causing changes in carrier concentration and carrier mobility. Based on this, graphene field-effect transistor (FET) biosensors modulated by applying a gate voltage have been widely studied, such as pH sensor, DNA biosensor, protein biosensor, and cell biosensor. [0003] Usually, in the graphene field effect tube biosensor, the chemical vapor deposition method is used to transfer single-layer or multi-layer graphene on the SiO2 or plastic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6818G01N27/414
CPCC12Q1/6818G01N27/4145C12Q2565/607C12Q2563/107
Inventor 岳伟伟谢晓慧汤彩艳华宏令张震李佳宁张哲豪
Owner SHANDONG NORMAL UNIV