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False tooth adhesive and preparation method thereof

An adhesive and denture technology, which is applied to dental preparations, pharmaceutical formulations, dental prostheses, etc., can solve the problems of short action time, insufficient bonding strength, insufficient action time, etc., and achieves simple preparation method, low production cost, easy-to-achieve effects

Inactive Publication Date: 2017-12-22
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, denture adhesives mainly include adhesive materials, antimicrobial agents, and additives. Among them, adhesive materials mainly include three types: natural rubber, animal and vegetable glue, cellulose, and polymer synthetic resin. After a while, the secreted colloid or the substances contained in the stems, leaves and roots can form colloids; animal and plant gums are widely found in the cell walls of animals and plants, and the main components of natural rubber and animal and plant gums are carbohydrates, hydrophilic groups There are many clusters and high hydrophilicity, which are easily washed away by saliva and water in the mouth, so that the effective time of DA is shortened, and its adhesion time is only about 5 hours, causing dentures to loosen and fall off. Groove bone resorption, gingival papilla hyperplasia; cellulose molecules are long-chain linear polymer compounds, which are easy to form hydrogen bonds, van der Waals forces and hydrophobic bonds with mucus proteins to play a role in bioadhesion, and the effect is fast , but the action time is short; polymer synthetic resin overcomes the shortcomings of natural rubber, animal and vegetable glue, and cellulose, which are easily soluble in water and has a short action time. It is widely used in various types of denture adhesives, but it is not easy to be Defects cleared
[0004] my country is the most populous country in the world, and the number of elderly people is also relatively the largest. With the improvement of living standards and medical technology, the average life expectancy of people is gradually increasing. After the elderly lose their teeth, the alveolar ridge becomes flat and the oral mucosa changes It is thin and loses elasticity, which brings great problems to the restoration of edentulous jaws. Usually, a better solution is to use dentures and assist the use of denture adhesives. However, at present, denture adhesives have insufficient bonding strength and function Disadvantages such as insufficient time or difficult removal

Method used

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  • False tooth adhesive and preparation method thereof
  • False tooth adhesive and preparation method thereof
  • False tooth adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of denture adhesive, is made up of base mixture and modified nano-diamond, the weight ratio of described modified nano-diamond and base mixture is 0.1%, and described base mixture is made up of following raw material: polyoxyethylene 0.3125g, carboxylate 0.1540 g of ethyl cellulose, 0.5625 g of montmorillonite, 1.2500 g of methyl cellulose, 0.5625 g of sodium alginate, and 12 ml of ethanol with a purity of 90%.

[0027] The modified nano-diamond is prepared by the following method: the nano-diamond is placed in a NaOH solution with a concentration of 0.11g / L, at a stirring speed of 60rpm and a temperature of 80°C, after stirring for 4h, the centrifugal speed is 4000rpm, Centrifuge for 30 minutes, take the precipitate and wash it repeatedly with deionized water until the pH value of the supernatant is 7; then dry it at 120°C for 4 hours, add to the silane coupling agent KH-550 with a mass fraction of 20% In the alcohol aqueous solution (the alcohol aqueous solutio...

Embodiment 2

[0033] A kind of denture adhesive, is made up of base mixture and modified nano-diamond, the weight ratio of described modified nano-diamond and base mixture is 0.05%, and described base mixture is made up of following raw material: polyoxyethylene 0.5g, carboxylate 0.1 g of ethyl cellulose, 0.6 g of montmorillonite, 2 g of methyl cellulose, 0.8 g of sodium alginate, and 13 ml of ethanol with a purity of 90%.

[0034] The modified nano-diamond is prepared by the following method: the nano-diamond is placed in a NaOH solution with a concentration of 0.11g / L, at a stirring speed of 100rpm and a temperature of 100°C, after stirring for 6h, the centrifugal speed is 4200rpm, Centrifuge for 10 minutes, take the precipitate and wash it repeatedly with deionized water until the pH value of the supernatant is 7; then dry it at 80°C for 12 hours, add to the silane coupling agent KH-550 with a mass fraction of 20% In the alcohol aqueous solution (the alcohol aqueous solution is prepared ...

Embodiment 3

[0040] A kind of denture adhesive, is made up of base mixture and modified nano-diamond, the weight ratio of described modified nano-diamond and base mixture is 0.3%, and described base mixture is made up of following raw material: polyoxyethylene 0.1g, carboxyl 0.4 g of ethyl cellulose, 0.8 g of montmorillonite, 1 g of methyl cellulose, 0.4 g of sodium alginate, and 12 ml of ethanol with a purity of 90%.

[0041] Refer to Example 1 for the preparation method of modified nano-diamond and denture adhesive.

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Abstract

The invention discloses a false tooth adhesive which is composed of a basic mixture and modified nano diamonds in a weight ratio of 0.01-0.5%. The basic mixture is prepared from the following raw materials: 0.1-0.5g of polyoxyethylenem, 0.1-0.4g of carboxyethyl cellulose, 0.4-0.8g of montmorillonite, 1-2g of methylcellulose, 0.4-0.8g of sodium alginate and 12-13ml of 90% ethanol. Meanwhile, the invention provides a corresponding preparation method thereof. By adding the nano diamonds into the false tooth adhesive, the false tooth adhesive has the advantages of free toxic or side effects to human body and stable chemical property, can reduce gaps among fillers effectively, and increase the duration among the fillers so as to play toughening and strengthening roles; meanwhile, the adhesive tensile strength of the false tooth adhesive is improved; the biocell toxicity of the false tooth adhesive can be reduced effectively; and the chewing efficiency and the cut end occlusal force of a false tooth patient can be improved effectively.

Description

technical field [0001] The invention relates to auxiliary products for dentures, in particular to a denture adhesive and a preparation method thereof. Background technique [0002] Denture adhesive (denture adhesive, DA) is an over-the-counter dental preparation made of adhesive materials. It is a type of material that temporarily assists denture retention. The denture adhesive is applied to the denture base tissue Afterwards, a substance thicker than saliva can be produced between the denture base and the mucous membrane of the supporting area to generate strong adhesion, and temporarily enhance the retention and stability of the denture through the adhesion with the oral mucosa, while the denture When the adhesive is first placed in the mouth, it is not very viscous, which is convenient for the patient to adjust the denture to the correct position, but it will quickly absorb water, expand, and discharge excess air and saliva between the base and the supporting area mucosa....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/097A61K6/087A61K6/06A61K6/027A61K6/00A61K6/891A61K6/898
CPCA61K6/15A61K6/35A61K6/831A61K6/86A61K6/891A61K6/898C08L5/04C08L1/286C08L1/28C08L71/02
Inventor 李真珍李骥杨晓鹏李秀娟王素云
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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