Composition for suppressing muscular fatty change

A technology of muscle fat and composition, which is applied in the field of composition for inhibiting muscle fat formation, can solve the problem of no inhibition of muscle satellite cell differentiation, and achieve the effect of improving muscle mass, high safety, and improving muscle strength

Inactive Publication Date: 2018-01-02
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, no components that inhibit the differentiation of muscle satellite cells into adipocyte-like cells have been found so far

Method used

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  • Composition for suppressing muscular fatty change
  • Composition for suppressing muscular fatty change
  • Composition for suppressing muscular fatty change

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Example 1: Fat accumulation inhibitory effect by quercetin

[0081] (1) Isolation of muscle satellite cells

[0082] The gastrocnemius, soleus, tibialis anterior, extensor digitorum longus, and quadriceps muscles were extracted from 10- to 14-week-old Fischer344 rats under anesthesia and chopped. The tissue was enzymatically decomposed with protease (Sigma-Aldrich), and then centrifuged to obtain a precipitate. The obtained precipitate was suspended in modified Eagle medium (DMEM) containing 10% fetal horse serum, and seeded on 8-well microscope slides (BD Thermo Scientific Company) as muscle satellite cells to become 5 × 10 4 ~7×10 4 cells / mL.

[0083] (2) Induction of differentiation into adipocyte-like cells

[0084] The isolated muscle satellite cells were cultured with F-10 (GIBCO) containing 20% ​​bovine serum for 72 hours. Thereafter, the cells were cultured for 72 hours in an adipogenic induction medium (Lonza) containing 0.1% DMSO (control), 5 µM quercetin...

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Abstract

The present invention addresses the problem of providing: a novel composition for suppressing muscular fatty change, which contains a component that can be ingested safely for a long period; and others. It is found that quercetin or a glycoside thereof can suppress the process of the differentiation of a muscle satellite cell into an adipocyte-like cell. In the present invention, quercetin or a glycoside thereof is used in a composition for suppressing muscular fatty change and the like.

Description

technical field [0001] The present invention relates to a composition for inhibiting muscle fat formation containing quercetin or a glycoside thereof. In addition, the present invention relates to a composition for inhibiting muscle fat formation, a composition for improving muscle mass, a composition for improving muscle strength, a composition for inhibiting muscle atrophy, and a composition for improving motor function, characterized in that it contains quercetin or its glycosides, and inhibit the differentiation of muscle satellite cells into adipocyte-like cells. Furthermore, the present invention also relates to the use of quercetin or its glycoside for inhibiting the differentiation process of muscle satellite cells into adipocyte-like cells and the inhibition of the differentiation process of muscle satellite cells into adipocyte-like cells using quercetin or its glycoside Methods. Background technique [0002] In a country with a high proportion of elderly people ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K31/7048A61P21/00A61P43/00
CPCA61K31/352A61K31/7048A61P21/00A61P43/00C07D311/30A61K31/353
Inventor 大塚祐多神崎范之町田修一
Owner SUNTORY HLDG LTD
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