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Aspirin injection used for relieving pain

An aspirin and injection technology, applied in the field of aspirin injection, can solve the problems of low solubility and low relative bioavailability of aspirin, and achieve the effects of avoiding gastrointestinal and cardiovascular side effects, improving pharmacokinetic properties, and being easy to prepare.

Inactive Publication Date: 2018-01-09
宫丽丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But fundamentally more than 80% of the effects of analgesics affect the gastric mucosa through blood circulation, which cannot be avoided by taking medicine after meals and using external analgesics; and the solubility of aspirin in water is low, water-soluble Properties: 3.3 g / L (20°C)
resulting in low relative bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] An aspirin injection for pain relief, characterized in that the components contain aspirin, a solvent and an antioxidant; the dosage ratio of the three (w / v / v): aspirin:solvent:antioxidant is 1:35:2; the solvent is poly Ethylene glycol; the antioxidant is phenothiazine with a mass fraction of 0.25%, and the concentration of polyethylene glycol 300 is 30%.

[0019] Aspirin (English: Aspirin), also known as acetylsalicylic acid, is an antipyretic and analgesic with a long history and has good antipyretic and analgesic effects. It is used to treat colds, fever, headache, toothache, arthralgia, rheumatism, and can also inhibit platelet aggregation. The drug effect is quick and sure, the overdose is easy to diagnose and handle, and allergic reactions rarely occur.

[0020] For the prevention and treatment of ischemic heart disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis. It is also effective in angioplasty and bypass grafting, so it is commonl...

Embodiment 2

[0024] Compared with Example 1, the types of raw materials are exactly the same, but the specific ratio of raw materials is different, and the similarities will not be repeated. The specific ratio of raw materials is as follows:

[0025] An aspirin injection for pain relief, characterized in that the components contain aspirin, a solvent and an antioxidant; the dosage ratio of the three (w / v / v): aspirin:solvent:antioxidant is 1:45:5; the solvent is formazan Oxy-polyethylene glycol, the antioxidant is 0.5% phenothiazine in mass fraction; the concentration of methoxy-polyethylene glycol is about 10%.

[0026] The solvent methoxypolyethylene glycol used in this injection has good water solubility, wettability, lubricity, physiological inertness, no stimulation to the human body, and mildness. In the pharmaceutical industry, it is used as ointment, emulsion, ointment, lotion and suppository bases. There is also a reaction between this product and acrylic acid containing polymeriz...

Embodiment 3

[0028] Compared with Example 1, the types of raw materials are exactly the same, but the specific ratio of raw materials is different, and the similarities will not be repeated. The specific ratio of raw materials is as follows:

[0029] An aspirin injection for pain relief, characterized in that the components contain aspirin, a solvent and an antioxidant; the dosage ratio of the three (w / v / v): aspirin:solvent:antioxidant: 1:25:3; the solvent is poly Propylene glycol, the antioxidant is phenothiazine with a mass fraction of 3%; the concentration of polypropylene glycol is about 15%.

[0030] The solvent polypropylene glycol used in this injection is a colorless to pale yellow viscous liquid. Not volatile. Non-corrosive. The molecular weight of general commodities is 400~2050. Lower molecular weight polymers are soluble in water. The most prominent feature of polypropylene glycol PPG is that it has wide compatibility with various volumes, wide annual range and hygroscopici...

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PUM

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Abstract

The invention discloses an aspirin injection used for relieving pain. The aspirin injection used for relieving pain contains aspirin, a solvent, and an anti-oxidant at a ratio (w / v / v) of 1: (7-45) : (2-5), and preferably at 1: (30-50) : (2-3); the solvent is one randomly selected from methoxy polyethylene glycol, polypropylene glycol, and polyethylene glycol; the anti-oxidant is phenthiazine witha mass concentration of 0.25% to 0.5%; the concentration of polyethylene glycol 300 ranges from 10 to 30%; the concentration of methoxy polyethylene glycol ranges from 10 to 25%; the concentration ofpolypropylene glycol ranges from 10 to 25%. The aspirin injection is used for parenteral administration instead of oral administration, so that stomach and cardiovascular side effects usually caused by oral pain relievers in clinical treatment are avoided; sustained slow release is realized; and long lasting drug release is realized.

Description

technical field [0001] The invention relates to an injection, in particular to an aspirin injection for relieving pain. Background technique [0002] Pain not only affects the quality of life, but some people may also develop mental illness due to long-term pain that cannot be effectively treated. Many pain patients, due to untimely treatment, make the local long-term universal pain transform into complex local pain syndrome or central pain, becoming an intractable pain disease. Therefore, the pain should be relieved in time. [0003] Aspirin is the antipyretic, analgesic and anti-inflammatory drug that is used the most and for a long time. It can inhibit the prostaglandin synthase in the thermoregulatory center, reduce the synthesis and release of prostaglandin (PGE1), and restore the normal responsiveness of the body temperature center. Peripheral blood vessels dilate and sweat, allowing body temperature to return to normal. Aspirin has anti-inflammatory and anti-rheuma...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/616A61K47/10A61K47/22A61P29/00A61P25/06A61P25/00
Inventor 李念虎陈西成宫丽丽景颖
Owner 宫丽丽
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